4XDK
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium channel subfamily K member 10 | polymer | 282 | 31060.1 | 4 | UniProt (P57789) Pfam (PF07885) | Homo sapiens (Human) | Outward rectifying potassium channel protein TREK-2,TREK-2 K(+) channel subunit |
| 2 | E, F, G, P, Q... (A, C) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 3 | H, I, M, N (A, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 4 | Chemie (PC1) | |||
| 4 | J, O, S, U (A, B, C) | (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine | non-polymer | 295.3 | 4 | Chemie (408) | |||
| 5 | K, L, T, V (A, C) | (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine | non-polymer | 295.3 | 4 | Chemie (405) |
Sequence modifications
A, B, C, D: 67 - 340 (UniProt: P57789)
| PDB | External Database | Details |
|---|---|---|
| Met 66 | - | initiating methionine |
| Ala 341 | - | expression tag |
| Glu 342 | - | expression tag |
| Asn 343 | - | expression tag |
| Leu 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Phe 346 | - | expression tag |
| Gln 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 124240.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5757.6 | |
| All* | Total formula weight | 129998.0 |
