Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4XDK

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport
C	0005267	molecular_function	potassium channel activity
C	0016020	cellular_component	membrane
C	0071805	biological_process	potassium ion transmembrane transport
D	0005267	molecular_function	potassium channel activity
D	0016020	cellular_component	membrane
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue K A 601

Chain	Residue
A	ILE173
A	GLY174
A	VAL282
A	GLY283
A	K602
B	ILE173
B	GLY174
B	VAL282
B	GLY283

site_id	AC2
Number of Residues	10
Details	binding site for residue K A 602

Chain	Residue
A	THR172
A	ILE173
A	THR281
A	VAL282
A	K601
A	K603
B	THR172
B	ILE173
B	THR281
B	VAL282

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 603

Chain	Residue
A	THR172
A	THR281
A	K602
B	THR172
B	THR281

site_id	AC4
Number of Residues	2
Details	binding site for residue PC1 A 604

Chain	Residue
A	VAL251
A	LEU304

site_id	AC5
Number of Residues	1
Details	binding site for residue PC1 A 605

Chain	Residue
A	ARG237

site_id	AC6
Number of Residues	7
Details	binding site for residue 408 A 606

Chain	Residue
A	CYS249
A	VAL253
A	LEU279
A	THR280
A	PHE316
B	ILE194
B	PRO198

site_id	AC7
Number of Residues	6
Details	binding site for residue 405 A 607

Chain	Residue
A	VAL253
A	LEU279
A	THR280
A	PHE316
B	ILE194
B	PRO198

site_id	AC8
Number of Residues	9
Details	binding site for residue 405 A 608

Chain	Residue
A	ILE194
A	PRO198
B	CYS249
B	VAL253
B	VAL276
B	LEU279
B	THR280
B	PHE316
B	LEU320

site_id	AC9
Number of Residues	2
Details	binding site for residue PC1 B 401

Chain	Residue
B	VAL251
B	LEU304

site_id	AD1
Number of Residues	8
Details	binding site for residue 408 B 403

Chain	Residue
A	ILE194
A	PRO198
B	CYS249
B	VAL253
B	VAL276
B	LEU279
B	THR280
B	PHE316

site_id	AD2
Number of Residues	9
Details	binding site for residue K C 601

Chain	Residue
C	ILE173
C	GLY174
C	VAL282
C	GLY283
C	K602
D	ILE173
D	GLY174
D	VAL282
D	GLY283

site_id	AD3
Number of Residues	10
Details	binding site for residue K C 602

Chain	Residue
C	THR172
C	ILE173
C	THR281
C	VAL282
C	K601
C	K603
D	THR172
D	ILE173
D	THR281
D	VAL282

site_id	AD4
Number of Residues	5
Details	binding site for residue K C 603

Chain	Residue
C	THR172
C	THR281
C	K602
D	THR172
D	THR281

site_id	AD5
Number of Residues	9
Details	binding site for residue 408 C 604

Chain	Residue
C	CYS249
C	VAL253
C	VAL276
C	LEU279
C	THR280
C	PHE316
D	ILE194
D	ILE197
D	PRO198

site_id	AD6
Number of Residues	8
Details	binding site for residue 405 C 605

Chain	Residue
D	PRO198
C	CYS249
C	VAL253
C	VAL276
C	LEU279
C	THR280
C	PHE316
D	ILE194

site_id	AD7
Number of Residues	8
Details	binding site for residue 408 C 606

Chain	Residue
C	ILE194
C	ILE197
C	PRO198
D	VAL253
D	LEU279
D	THR280
D	LEU313
D	PHE316

site_id	AD8
Number of Residues	6
Details	binding site for residue 405 C 607

Chain	Residue
C	ILE194
C	PRO198
D	VAL253
D	LEU279
D	LEU313
D	PHE316

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	MET72-GLY92
C	THR182-PHE202
C	THR234-THR254
C	GLU299-VAL319
D	MET72-GLY92
D	THR182-PHE202
D	THR234-THR254
D	GLU299-VAL319
A	THR182-PHE202
A	THR234-THR254
A	GLU299-VAL319
B	MET72-GLY92
B	THR182-PHE202
B	THR234-THR254
B	GLU299-VAL319
C	MET72-GLY92

site_id	SWS_FT_FI2
Number of Residues	104
Details	INTRAMEM: Pore-forming; Name=Pore-forming 1 => ECO:0007744\|PDB:4BW5

Chain	Residue	Details
A	SER154-PRO180
B	SER154-PRO180
C	SER154-PRO180
D	SER154-PRO180

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LEU203-GLN233
B	LEU203-GLN233
C	LEU203-GLN233
D	LEU203-GLN233

site_id	SWS_FT_FI4
Number of Residues	124
Details	INTRAMEM: Pore-forming; Name=Pore-forming 2 => ECO:0007744\|PDB:4BW5

Chain	Residue	Details
A	ILE263-GLY294
B	ILE263-GLY294
C	ILE263-GLY294
D	ILE263-GLY294

site_id	SWS_FT_FI5
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:25766236, ECO:0007744\|PDB:4XDK

Chain	Residue	Details
A	GLY167
B	THR168
B	VAL169
B	ILE170
B	VAL276
B	VAL277
B	THR278
B	LEU279
C	GLY167
C	THR168
C	VAL169
A	THR168
C	ILE170
C	VAL276
C	VAL277
C	THR278
C	LEU279
D	GLY167
D	THR168
D	VAL169
D	ILE170
D	VAL276
A	VAL169
D	VAL277
D	THR278
D	LEU279
A	ILE170
A	VAL276
A	VAL277
A	THR278
A	LEU279
B	GLY167

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: pH sensor => ECO:0000250\|UniProtKB:Q8BUW1

Chain	Residue	Details
A	SER151
B	SER151
C	SER151
D	SER151

site_id	SWS_FT_FI7
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	VAL144
D	VAL144
D	ILE147
D	GLY148
A	ILE147
A	GLY148
B	VAL144
B	ILE147
B	GLY148
C	VAL144
C	ILE147
C	GLY148

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)