4XA5
Crystal structure of the pre-catalytic ternary complex of DNA polymerase lambda with a templating A and an incoming 8-oxo-dGTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase lambda | polymer | 325 | 36552.6 | 1 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | Pol Lambda,DNA polymerase beta-2,Pol beta2,DNA polymerase kappa |
| 2 | B (D) | DOWNSTREAM PRIMER DNA (5'-D(P*GP*CP*CP*G)-3') | polymer | 4 | 1191.8 | 1 | synthetic construct | ||
| 3 | C (P) | PRIMER DNA (5'-D(*CP*AP*GP*TP*AP*(DOC))-3') | polymer | 6 | 1777.2 | 1 | synthetic construct | ||
| 4 | D (T) | TEMPLATE DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3') | polymer | 11 | 3374.2 | 1 | synthetic construct | ||
| 5 | E (A) | 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (8DG) | |||
| 6 | F, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | H, I, J (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 8 | K, L (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | M, N, O, P (A, D, P, T) | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 42895.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 933.1 | |
| All* | Total formula weight | 43828.9 |
