4X41

Crystal Structure of Protein Arginine Methyltransferase PRMT8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein arginine N-methyltransferase 8	polymer	358	41614.5	2	UniProt (Q9NR22) Pfam (PF06325) Pfam (PF22528)	Homo sapiens (Human)	Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
2	C (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)

Sequence modifications

A, B: 61 - 394 (UniProt: Q9NR22)

PDB	External Database	Details
Met 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Val 47	-	expression tag
Asp 48	-	expression tag
Leu 49	-	expression tag
Gly 50	-	expression tag
Thr 51	-	expression tag
Glu 52	-	expression tag
Asn 53	-	expression tag
Leu 54	-	expression tag
Tyr 55	-	expression tag
Phe 56	-	expression tag
Gln 57	-	expression tag
Ser 58	-	expression tag
Asn 59	-	expression tag
Gly 60	-	expression tag
Gln 150	Glu 141	see sequence details

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83229.0
Non-Polymers*	Number of molecules	1
	Total formula weight	384.4
All*	Total formula weight	83613.5

*Water molecules are not included.