4X41

Crystal Structure of Protein Arginine Methyltransferase PRMT8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue SAH A 401

Chain	Residue
A	HIS86
A	GLU141
A	CYS142
A	GLY167
A	LYS168
A	VAL169
A	GLU185
A	MET196
A	THR199
A	ARG95
A	GLY119
A	SER120
A	GLY121
A	THR122
A	ILE124
A	LEU125
A	ILE140

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Functional Information from PROSITE/UniProt

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. VLDVGSGTgilSMF

Chain	Residue	Details
A	VAL115-PHE128

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q63009","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q63009","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26529540","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26876602","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4X41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DST","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26876602","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5DST","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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