4WXP
X-ray crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor at 2.08 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NS3-4 protease | polymer | 451 | 48302.7 | 1 | UniProt (K7XFN2) Pfam (PF07652) Pfam (PF22027) UniProt (by SIFTS) (P26663) | Hepatitis C virus | |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | (1-methyl-1H-indol-3-yl)acetic acid | non-polymer | 189.2 | 1 | Chemie (3VY) | |||
| 5 | E (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 180 - 630 (UniProt: K7XFN2)
| PDB | External Database | Details |
|---|---|---|
| Ser 196 | Thr 196 | conflict |
| Ile 248 | Val 248 | conflict |
| Ala 258 | Thr 258 | conflict |
| Gly 263 | Ala 263 | conflict |
| Ser 332 | Pro 332 | conflict |
| Val 358 | Thr 358 | conflict |
| Arg 360 | Lys 360 | conflict |
| Ala 383 | Gly 383 | conflict |
| Asp 447 | Glu 447 | conflict |
| Arg 470 | Gly 470 | conflict |
| Ser 584 | Cys 584 | conflict |
| Thr 586 | Ile 586 | conflict |
| Leu 593 | His 593 | conflict |
| Pro 595 | Ser 595 | conflict |
| Leu 605 | Val 605 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48302.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 247.7 | |
| All* | Total formula weight | 48550.3 |
