4WXP
X-ray crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor at 2.08 A resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NS3-4 protease | polymer | 451 | 48302.7 | 1 | UniProt (K7XFN2) Pfam (PF07652) Pfam (PF22027) UniProt (by SIFTS) (P26663) In PDB | Hepatitis C virus | |
2 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | A | (1-methyl-1H-indol-3-yl)acetic acid | non-polymer | 189.2 | 1 | Chemie (3VY) | |||
5 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 180 - 630 (UniProt: K7XFN2)
PDB | External Database | Details |
---|---|---|
Ser 196 | Thr 196 | conflict |
Ile 248 | Val 248 | conflict |
Ala 258 | Thr 258 | conflict |
Gly 263 | Ala 263 | conflict |
Ser 332 | Pro 332 | conflict |
Val 358 | Thr 358 | conflict |
Arg 360 | Lys 360 | conflict |
Ala 383 | Gly 383 | conflict |
Asp 447 | Glu 447 | conflict |
Arg 470 | Gly 470 | conflict |
Ser 584 | Cys 584 | conflict |
Thr 586 | Ile 586 | conflict |
Leu 593 | His 593 | conflict |
Pro 595 | Ser 595 | conflict |
Leu 605 | Val 605 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 48302.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 247.7 | |
All* | Total formula weight | 48550.3 |