4WXP

X-ray crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor at 2.08 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NA A 701

Chain	Residue
A	ASN387
A	ASN387
A	HOH802

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 702

Chain	Residue
A	GLY209
A	SER211
A	THR212
A	HOH815

---

site_id	AC3
Number of Residues	9
Details	binding site for residue 3VY A 703

Chain	Residue
A	GLY255
A	THR269
A	GLY271
A	LYS272
A	ALA275
A	TYR502
A	HOH900
A	VAL232
A	THR254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"9614113","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DECH box","evidences":[{"source":"UniProtKB","id":"Q99IB8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9WMX2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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