4WWY
human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Trypsin-1 | polymer | 224 | 24218.3 | 2 | UniProt (P07477) Pfam (PF00089) | Homo sapiens (Human) | Beta-trypsin,Cationic trypsinogen,Serine protease 1,Trypsin I |
| 2 | C, D (C, I) | Pancreatic trypsin inhibitor | polymer | 58 | 6527.6 | 2 | UniProt (P00974) Pfam (PF00014) | Bos taurus (Bovine) | Aprotinin,Basic protease inhibitor,BPTI |
| 3 | E, F, G, I, J... (A, B, C, I) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | H (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | N, O, P, Q (A, B, C, I) | water | water | 18.0 | 390 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 246 (UniProt: P07477)
| PDB | External Database | Details |
|---|---|---|
| His 117 | Arg 122 | engineered mutation |
| Arg 193 | Gly 198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61491.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 808.6 | |
| All* | Total formula weight | 62300.3 |
