Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0072562 | cellular_component | blood microparticle |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0007586 | biological_process | digestion |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0072562 | cellular_component | blood microparticle |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| I | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | LYS60 |
| A | SER61 |
| A | HOH489 |
| C | LYS46 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | THR177 |
| A | SER178 |
| A | HOH526 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | HOH536 |
| A | ARG111 |
| A | HOH433 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 301 |
| Chain | Residue |
| B | HIS40 |
| B | ARG66 |
| B | GLU70 |
| B | ILE73 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | LYS97 |
| B | LEU99 |
| B | LYS175 |
| B | TRP215 |
| B | HOH422 |
| I | ARG39 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 C 101 |
| Chain | Residue |
| A | ARG96 |
| A | HOH429 |
| C | ARG20 |
| C | TYR35 |
| C | GLY37 |
| C | ARG39 |
| C | ALA40 |
| C | HOH201 |
| C | HOH202 |
| C | HOH209 |
| C | HOH233 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 102 |
| Chain | Residue |
| C | GLU7 |
| C | ARG42 |
| C | HOH210 |
| C | HOH214 |
| C | HOH215 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 I 101 |
| Chain | Residue |
| I | GLU7 |
| I | LYS41 |
| I | ARG42 |
| I | HOH222 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 I 102 |
| Chain | Residue |
| B | ARG96 |
| B | HOH452 |
| I | ARG20 |
| I | TYR35 |
| I | GLY37 |
| I | ARG39 |
| I | ALA40 |
| I | HOH202 |
| I | HOH206 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAGHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGCrakrnnFksaedC |
| Chain | Residue | Details |
| C | PHE33-CYS51 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for specificity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"17087724","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25010489","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 100 |
| Details | Domain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive bond for trypsin"} |
