4WSN

Crystal structure of the COP9 signalosome, a P1 crystal form

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, GA, I, OA, Q... (A, I, Q, Y, g...)	COP9 signalosome complex subunit 1	polymer	480	54222.8	6	UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151)	Homo sapiens (Human)	Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH
2	B, HA, J, PA, R... (B, J, R, Z, h...)	COP9 signalosome complex subunit 2	polymer	447	51992.9	6	UniProt (P61201) Pfam (PF01399)	Homo sapiens (Human)	Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15
3	AA, C, IA, K, QA... (C, K, S, a, i...)	COP9 signalosome complex subunit 3	polymer	427	48252.4	6	UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215)	Homo sapiens (Human)	Signalosome subunit 3,JAB1-containing signalosome subunit 3
4	BA, D, JA, L, RA... (D, L, T, b, j...)	COP9 signalosome complex subunit 4	polymer	410	46651.0	6	UniProt (Q9BT78) Pfam (PF18420) Pfam (PF22241) Pfam (PF01399)	Homo sapiens (Human)	Signalosome subunit 4,JAB1-containing signalosome subunit 4
5	CA, E, KA, M, SA... (E, M, U, c, k...)	COP9 signalosome complex subunit 5	polymer	325	36641.6	6	UniProt (Q92905) Pfam (PF01398) Pfam (PF18323)	Homo sapiens (Human)	Signalosome subunit 5,Jun activation domain-binding protein 1
6	DA, F, LA, N, TA... (F, N, V, d, l...)	COP9 signalosome complex subunit 6	polymer	331	36531.7	6	UniProt (Q7L5N1) Pfam (PF01398) Pfam (PF13012)	Homo sapiens (Human)	Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP
7	EA, G, MA, O, UA... (G, O, W, e, m...)	COP9 signalosome complex subunit 7a	polymer	222	24649.2	6	UniProt (Q9UBW8) Pfam (PF22061) Pfam (PF01399) Pfam (PF18392)	Homo sapiens (Human)	Signalosome subunit 7a,Dermal papilla-derived protein 10,JAB1-containing signalosome subunit 7a
8	FA, H, NA, P, VA... (H, P, X, f, n...)	COP9 signalosome complex subunit 8	polymer	213	23573.9	6	UniProt (Q99627) Pfam (PF10075)	Homo sapiens (Human)	Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8
9	AB, BB, WA, XA, YA... (k, s, E, M, U...)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)

Sequence modifications

A, I, Q, Y, g, o: 52 - 527 (UniProt: Q13098)

PDB	External Database	Details
Gly 48	-	expression tag
Gly 49	-	expression tag
Gly 50	-	expression tag
Arg 51	-	expression tag

B, J, R, Z, h, p: 1 - 443 (UniProt: P61201)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

C, K, S, a, i, q: 1 - 423 (UniProt: Q9UNS2)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

D, L, T, b, j, r: 1 - 406 (UniProt: Q9BT78)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

E, M, U, c, k, s: 14 - 334 (UniProt: Q92905)

PDB	External Database	Details
Gly 10	-	expression tag
Gly 11	-	expression tag
Gly 12	-	expression tag
Arg 13	-	expression tag

F, N, V, d, l, t: 1 - 327 (UniProt: Q7L5N1)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

G, O, W, e, m, u: 1 - 218 (UniProt: Q9UBW8)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

H, P, X, f, n, v: 1 - 209 (UniProt: Q99627)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	48
	Total formula weight	1935093.3
Non-Polymers*	Number of molecules	6
	Total formula weight	392.5
All*	Total formula weight	1935485.8

*Water molecules are not included.