Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WSN

Crystal structure of the COP9 signalosome, a P1 crystal form

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000338	biological_process	protein deneddylation
a	0001701	biological_process	in utero embryonic development
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0007165	biological_process	signal transduction
a	0008180	cellular_component	COP9 signalosome
a	0009416	biological_process	response to light stimulus
a	0032991	cellular_component	protein-containing complex
a	0045116	biological_process	protein neddylation
a	0048471	cellular_component	perinuclear region of cytoplasm
a	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
a	2000434	biological_process	regulation of protein neddylation
A	0000338	biological_process	protein deneddylation
A	0005095	molecular_function	GTPase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007254	biological_process	JNK cascade
A	0008180	cellular_component	COP9 signalosome
A	0032991	cellular_component	protein-containing complex
A	0045116	biological_process	protein neddylation
A	2000434	biological_process	regulation of protein neddylation
b	0000338	biological_process	protein deneddylation
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0008021	cellular_component	synaptic vesicle
b	0008180	cellular_component	COP9 signalosome
b	0016607	cellular_component	nuclear speck
b	0019784	molecular_function	deNEDDylase activity
b	0030054	cellular_component	cell junction
b	0031410	cellular_component	cytoplasmic vesicle
b	0032991	cellular_component	protein-containing complex
b	0045116	biological_process	protein neddylation
b	0045202	cellular_component	synapse
b	2000434	biological_process	regulation of protein neddylation
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000338	biological_process	protein deneddylation
B	0001833	biological_process	inner cell mass cell proliferation
B	0001834	biological_process	trophectodermal cell proliferation
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006366	biological_process	transcription by RNA polymerase II
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0008180	cellular_component	COP9 signalosome
B	0030182	biological_process	neuron differentiation
B	0032991	cellular_component	protein-containing complex
B	0035914	biological_process	skeletal muscle cell differentiation
B	0045116	biological_process	protein neddylation
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	2000434	biological_process	regulation of protein neddylation
c	0000338	biological_process	protein deneddylation
c	0000785	cellular_component	chromatin
c	0003713	molecular_function	transcription coactivator activity
c	0003743	molecular_function	translation initiation factor activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
c	0006412	biological_process	translation
c	0006413	biological_process	translational initiation
c	0006508	biological_process	proteolysis
c	0008021	cellular_component	synaptic vesicle
c	0008180	cellular_component	COP9 signalosome
c	0008233	molecular_function	peptidase activity
c	0008237	molecular_function	metallopeptidase activity
c	0019784	molecular_function	deNEDDylase activity
c	0019899	molecular_function	enzyme binding
c	0031410	cellular_component	cytoplasmic vesicle
c	0035718	molecular_function	macrophage migration inhibitory factor binding
c	0043066	biological_process	negative regulation of apoptotic process
c	0043687	biological_process	post-translational protein modification
c	0045116	biological_process	protein neddylation
c	0045202	cellular_component	synapse
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0046328	biological_process	regulation of JNK cascade
c	0046872	molecular_function	metal ion binding
c	0048471	cellular_component	perinuclear region of cytoplasm
c	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
c	0051726	biological_process	regulation of cell cycle
c	0140492	molecular_function	metal-dependent deubiquitinase activity
c	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
c	1990182	biological_process	exosomal secretion
c	2000434	biological_process	regulation of protein neddylation
C	0000338	biological_process	protein deneddylation
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007165	biological_process	signal transduction
C	0008180	cellular_component	COP9 signalosome
C	0009416	biological_process	response to light stimulus
C	0032991	cellular_component	protein-containing complex
C	0045116	biological_process	protein neddylation
C	0048471	cellular_component	perinuclear region of cytoplasm
C	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
C	2000434	biological_process	regulation of protein neddylation
d	0000338	biological_process	protein deneddylation
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0008180	cellular_component	COP9 signalosome
d	0008233	molecular_function	peptidase activity
d	0008237	molecular_function	metallopeptidase activity
d	0045116	biological_process	protein neddylation
d	0048471	cellular_component	perinuclear region of cytoplasm
d	0140492	molecular_function	metal-dependent deubiquitinase activity
d	2000434	biological_process	regulation of protein neddylation
D	0000338	biological_process	protein deneddylation
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008021	cellular_component	synaptic vesicle
D	0008180	cellular_component	COP9 signalosome
D	0016607	cellular_component	nuclear speck
D	0019784	molecular_function	deNEDDylase activity
D	0030054	cellular_component	cell junction
D	0031410	cellular_component	cytoplasmic vesicle
D	0032991	cellular_component	protein-containing complex
D	0045116	biological_process	protein neddylation
D	0045202	cellular_component	synapse
D	2000434	biological_process	regulation of protein neddylation
e	0008180	cellular_component	COP9 signalosome
e	0010387	biological_process	COP9 signalosome assembly
E	0000338	biological_process	protein deneddylation
E	0000785	cellular_component	chromatin
E	0003713	molecular_function	transcription coactivator activity
E	0003743	molecular_function	translation initiation factor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006508	biological_process	proteolysis
E	0008021	cellular_component	synaptic vesicle
E	0008180	cellular_component	COP9 signalosome
E	0008233	molecular_function	peptidase activity
E	0008237	molecular_function	metallopeptidase activity
E	0019784	molecular_function	deNEDDylase activity
E	0019899	molecular_function	enzyme binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0035718	molecular_function	macrophage migration inhibitory factor binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0043687	biological_process	post-translational protein modification
E	0045116	biological_process	protein neddylation
E	0045202	cellular_component	synapse
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046328	biological_process	regulation of JNK cascade
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
E	0051726	biological_process	regulation of cell cycle
E	0140492	molecular_function	metal-dependent deubiquitinase activity
E	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
E	1990182	biological_process	exosomal secretion
E	2000434	biological_process	regulation of protein neddylation
f	0000338	biological_process	protein deneddylation
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006468	biological_process	protein phosphorylation
f	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
f	0008180	cellular_component	COP9 signalosome
f	0008285	biological_process	negative regulation of cell population proliferation
f	0010387	biological_process	COP9 signalosome assembly
f	0045116	biological_process	protein neddylation
f	0048471	cellular_component	perinuclear region of cytoplasm
f	0070062	cellular_component	extracellular exosome
f	2000434	biological_process	regulation of protein neddylation
F	0000338	biological_process	protein deneddylation
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008180	cellular_component	COP9 signalosome
F	0008233	molecular_function	peptidase activity
F	0008237	molecular_function	metallopeptidase activity
F	0045116	biological_process	protein neddylation
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0140492	molecular_function	metal-dependent deubiquitinase activity
F	2000434	biological_process	regulation of protein neddylation
g	0000338	biological_process	protein deneddylation
g	0005095	molecular_function	GTPase inhibitor activity
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0007254	biological_process	JNK cascade
g	0008180	cellular_component	COP9 signalosome
g	0032991	cellular_component	protein-containing complex
g	0045116	biological_process	protein neddylation
g	2000434	biological_process	regulation of protein neddylation
G	0008180	cellular_component	COP9 signalosome
G	0010387	biological_process	COP9 signalosome assembly
h	0000122	biological_process	negative regulation of transcription by RNA polymerase II
h	0000338	biological_process	protein deneddylation
h	0001833	biological_process	inner cell mass cell proliferation
h	0001834	biological_process	trophectodermal cell proliferation
h	0003714	molecular_function	transcription corepressor activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006366	biological_process	transcription by RNA polymerase II
h	0006468	biological_process	protein phosphorylation
h	0007165	biological_process	signal transduction
h	0008180	cellular_component	COP9 signalosome
h	0030182	biological_process	neuron differentiation
h	0032991	cellular_component	protein-containing complex
h	0035914	biological_process	skeletal muscle cell differentiation
h	0045116	biological_process	protein neddylation
h	0045892	biological_process	negative regulation of DNA-templated transcription
h	2000434	biological_process	regulation of protein neddylation
H	0000338	biological_process	protein deneddylation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006468	biological_process	protein phosphorylation
H	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
H	0008180	cellular_component	COP9 signalosome
H	0008285	biological_process	negative regulation of cell population proliferation
H	0010387	biological_process	COP9 signalosome assembly
H	0045116	biological_process	protein neddylation
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0070062	cellular_component	extracellular exosome
H	2000434	biological_process	regulation of protein neddylation
i	0000338	biological_process	protein deneddylation
i	0001701	biological_process	in utero embryonic development
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
i	0007165	biological_process	signal transduction
i	0008180	cellular_component	COP9 signalosome
i	0009416	biological_process	response to light stimulus
i	0032991	cellular_component	protein-containing complex
i	0045116	biological_process	protein neddylation
i	0048471	cellular_component	perinuclear region of cytoplasm
i	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
i	2000434	biological_process	regulation of protein neddylation
I	0000338	biological_process	protein deneddylation
I	0005095	molecular_function	GTPase inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007254	biological_process	JNK cascade
I	0008180	cellular_component	COP9 signalosome
I	0032991	cellular_component	protein-containing complex
I	0045116	biological_process	protein neddylation
I	2000434	biological_process	regulation of protein neddylation
j	0000338	biological_process	protein deneddylation
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0008021	cellular_component	synaptic vesicle
j	0008180	cellular_component	COP9 signalosome
j	0016607	cellular_component	nuclear speck
j	0019784	molecular_function	deNEDDylase activity
j	0030054	cellular_component	cell junction
j	0031410	cellular_component	cytoplasmic vesicle
j	0032991	cellular_component	protein-containing complex
j	0045116	biological_process	protein neddylation
j	0045202	cellular_component	synapse
j	2000434	biological_process	regulation of protein neddylation
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000338	biological_process	protein deneddylation
J	0001833	biological_process	inner cell mass cell proliferation
J	0001834	biological_process	trophectodermal cell proliferation
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006366	biological_process	transcription by RNA polymerase II
J	0006468	biological_process	protein phosphorylation
J	0007165	biological_process	signal transduction
J	0008180	cellular_component	COP9 signalosome
J	0030182	biological_process	neuron differentiation
J	0032991	cellular_component	protein-containing complex
J	0035914	biological_process	skeletal muscle cell differentiation
J	0045116	biological_process	protein neddylation
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	2000434	biological_process	regulation of protein neddylation
k	0000338	biological_process	protein deneddylation
k	0000785	cellular_component	chromatin
k	0003713	molecular_function	transcription coactivator activity
k	0003743	molecular_function	translation initiation factor activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
k	0006412	biological_process	translation
k	0006413	biological_process	translational initiation
k	0006508	biological_process	proteolysis
k	0008021	cellular_component	synaptic vesicle
k	0008180	cellular_component	COP9 signalosome
k	0008233	molecular_function	peptidase activity
k	0008237	molecular_function	metallopeptidase activity
k	0019784	molecular_function	deNEDDylase activity
k	0019899	molecular_function	enzyme binding
k	0031410	cellular_component	cytoplasmic vesicle
k	0035718	molecular_function	macrophage migration inhibitory factor binding
k	0043066	biological_process	negative regulation of apoptotic process
k	0043687	biological_process	post-translational protein modification
k	0045116	biological_process	protein neddylation
k	0045202	cellular_component	synapse
k	0045944	biological_process	positive regulation of transcription by RNA polymerase II
k	0046328	biological_process	regulation of JNK cascade
k	0046872	molecular_function	metal ion binding
k	0048471	cellular_component	perinuclear region of cytoplasm
k	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
k	0051726	biological_process	regulation of cell cycle
k	0140492	molecular_function	metal-dependent deubiquitinase activity
k	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
k	1990182	biological_process	exosomal secretion
k	2000434	biological_process	regulation of protein neddylation
K	0000338	biological_process	protein deneddylation
K	0001701	biological_process	in utero embryonic development
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0007165	biological_process	signal transduction
K	0008180	cellular_component	COP9 signalosome
K	0009416	biological_process	response to light stimulus
K	0032991	cellular_component	protein-containing complex
K	0045116	biological_process	protein neddylation
K	0048471	cellular_component	perinuclear region of cytoplasm
K	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
K	2000434	biological_process	regulation of protein neddylation
l	0000338	biological_process	protein deneddylation
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0008180	cellular_component	COP9 signalosome
l	0008233	molecular_function	peptidase activity
l	0008237	molecular_function	metallopeptidase activity
l	0045116	biological_process	protein neddylation
l	0048471	cellular_component	perinuclear region of cytoplasm
l	0140492	molecular_function	metal-dependent deubiquitinase activity
l	2000434	biological_process	regulation of protein neddylation
L	0000338	biological_process	protein deneddylation
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0008021	cellular_component	synaptic vesicle
L	0008180	cellular_component	COP9 signalosome
L	0016607	cellular_component	nuclear speck
L	0019784	molecular_function	deNEDDylase activity
L	0030054	cellular_component	cell junction
L	0031410	cellular_component	cytoplasmic vesicle
L	0032991	cellular_component	protein-containing complex
L	0045116	biological_process	protein neddylation
L	0045202	cellular_component	synapse
L	2000434	biological_process	regulation of protein neddylation
m	0008180	cellular_component	COP9 signalosome
m	0010387	biological_process	COP9 signalosome assembly
M	0000338	biological_process	protein deneddylation
M	0000785	cellular_component	chromatin
M	0003713	molecular_function	transcription coactivator activity
M	0003743	molecular_function	translation initiation factor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
M	0006508	biological_process	proteolysis
M	0008021	cellular_component	synaptic vesicle
M	0008180	cellular_component	COP9 signalosome
M	0008233	molecular_function	peptidase activity
M	0008237	molecular_function	metallopeptidase activity
M	0019784	molecular_function	deNEDDylase activity
M	0019899	molecular_function	enzyme binding
M	0031410	cellular_component	cytoplasmic vesicle
M	0035718	molecular_function	macrophage migration inhibitory factor binding
M	0043066	biological_process	negative regulation of apoptotic process
M	0043687	biological_process	post-translational protein modification
M	0045116	biological_process	protein neddylation
M	0045202	cellular_component	synapse
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046328	biological_process	regulation of JNK cascade
M	0046872	molecular_function	metal ion binding
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
M	0051726	biological_process	regulation of cell cycle
M	0140492	molecular_function	metal-dependent deubiquitinase activity
M	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
M	1990182	biological_process	exosomal secretion
M	2000434	biological_process	regulation of protein neddylation
n	0000338	biological_process	protein deneddylation
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006468	biological_process	protein phosphorylation
n	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
n	0008180	cellular_component	COP9 signalosome
n	0008285	biological_process	negative regulation of cell population proliferation
n	0010387	biological_process	COP9 signalosome assembly
n	0045116	biological_process	protein neddylation
n	0048471	cellular_component	perinuclear region of cytoplasm
n	0070062	cellular_component	extracellular exosome
n	2000434	biological_process	regulation of protein neddylation
N	0000338	biological_process	protein deneddylation
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0008180	cellular_component	COP9 signalosome
N	0008233	molecular_function	peptidase activity
N	0008237	molecular_function	metallopeptidase activity
N	0045116	biological_process	protein neddylation
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0140492	molecular_function	metal-dependent deubiquitinase activity
N	2000434	biological_process	regulation of protein neddylation
o	0000338	biological_process	protein deneddylation
o	0005095	molecular_function	GTPase inhibitor activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0007254	biological_process	JNK cascade
o	0008180	cellular_component	COP9 signalosome
o	0032991	cellular_component	protein-containing complex
o	0045116	biological_process	protein neddylation
o	2000434	biological_process	regulation of protein neddylation
O	0008180	cellular_component	COP9 signalosome
O	0010387	biological_process	COP9 signalosome assembly
p	0000122	biological_process	negative regulation of transcription by RNA polymerase II
p	0000338	biological_process	protein deneddylation
p	0001833	biological_process	inner cell mass cell proliferation
p	0001834	biological_process	trophectodermal cell proliferation
p	0003714	molecular_function	transcription corepressor activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0006366	biological_process	transcription by RNA polymerase II
p	0006468	biological_process	protein phosphorylation
p	0007165	biological_process	signal transduction
p	0008180	cellular_component	COP9 signalosome
p	0030182	biological_process	neuron differentiation
p	0032991	cellular_component	protein-containing complex
p	0035914	biological_process	skeletal muscle cell differentiation
p	0045116	biological_process	protein neddylation
p	0045892	biological_process	negative regulation of DNA-templated transcription
p	2000434	biological_process	regulation of protein neddylation
P	0000338	biological_process	protein deneddylation
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006468	biological_process	protein phosphorylation
P	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
P	0008180	cellular_component	COP9 signalosome
P	0008285	biological_process	negative regulation of cell population proliferation
P	0010387	biological_process	COP9 signalosome assembly
P	0045116	biological_process	protein neddylation
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0070062	cellular_component	extracellular exosome
P	2000434	biological_process	regulation of protein neddylation
q	0000338	biological_process	protein deneddylation
q	0001701	biological_process	in utero embryonic development
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0006511	biological_process	ubiquitin-dependent protein catabolic process
q	0007165	biological_process	signal transduction
q	0008180	cellular_component	COP9 signalosome
q	0009416	biological_process	response to light stimulus
q	0032991	cellular_component	protein-containing complex
q	0045116	biological_process	protein neddylation
q	0048471	cellular_component	perinuclear region of cytoplasm
q	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
q	2000434	biological_process	regulation of protein neddylation
Q	0000338	biological_process	protein deneddylation
Q	0005095	molecular_function	GTPase inhibitor activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0007254	biological_process	JNK cascade
Q	0008180	cellular_component	COP9 signalosome
Q	0032991	cellular_component	protein-containing complex
Q	0045116	biological_process	protein neddylation
Q	2000434	biological_process	regulation of protein neddylation
r	0000338	biological_process	protein deneddylation
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0008021	cellular_component	synaptic vesicle
r	0008180	cellular_component	COP9 signalosome
r	0016607	cellular_component	nuclear speck
r	0019784	molecular_function	deNEDDylase activity
r	0030054	cellular_component	cell junction
r	0031410	cellular_component	cytoplasmic vesicle
r	0032991	cellular_component	protein-containing complex
r	0045116	biological_process	protein neddylation
r	0045202	cellular_component	synapse
r	2000434	biological_process	regulation of protein neddylation
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000338	biological_process	protein deneddylation
R	0001833	biological_process	inner cell mass cell proliferation
R	0001834	biological_process	trophectodermal cell proliferation
R	0003714	molecular_function	transcription corepressor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006366	biological_process	transcription by RNA polymerase II
R	0006468	biological_process	protein phosphorylation
R	0007165	biological_process	signal transduction
R	0008180	cellular_component	COP9 signalosome
R	0030182	biological_process	neuron differentiation
R	0032991	cellular_component	protein-containing complex
R	0035914	biological_process	skeletal muscle cell differentiation
R	0045116	biological_process	protein neddylation
R	0045892	biological_process	negative regulation of DNA-templated transcription
R	2000434	biological_process	regulation of protein neddylation
s	0000338	biological_process	protein deneddylation
s	0000785	cellular_component	chromatin
s	0003713	molecular_function	transcription coactivator activity
s	0003743	molecular_function	translation initiation factor activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
s	0006412	biological_process	translation
s	0006413	biological_process	translational initiation
s	0006508	biological_process	proteolysis
s	0008021	cellular_component	synaptic vesicle
s	0008180	cellular_component	COP9 signalosome
s	0008233	molecular_function	peptidase activity
s	0008237	molecular_function	metallopeptidase activity
s	0019784	molecular_function	deNEDDylase activity
s	0019899	molecular_function	enzyme binding
s	0031410	cellular_component	cytoplasmic vesicle
s	0035718	molecular_function	macrophage migration inhibitory factor binding
s	0043066	biological_process	negative regulation of apoptotic process
s	0043687	biological_process	post-translational protein modification
s	0045116	biological_process	protein neddylation
s	0045202	cellular_component	synapse
s	0045944	biological_process	positive regulation of transcription by RNA polymerase II
s	0046328	biological_process	regulation of JNK cascade
s	0046872	molecular_function	metal ion binding
s	0048471	cellular_component	perinuclear region of cytoplasm
s	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
s	0051726	biological_process	regulation of cell cycle
s	0140492	molecular_function	metal-dependent deubiquitinase activity
s	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
s	1990182	biological_process	exosomal secretion
s	2000434	biological_process	regulation of protein neddylation
S	0000338	biological_process	protein deneddylation
S	0001701	biological_process	in utero embryonic development
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0007165	biological_process	signal transduction
S	0008180	cellular_component	COP9 signalosome
S	0009416	biological_process	response to light stimulus
S	0032991	cellular_component	protein-containing complex
S	0045116	biological_process	protein neddylation
S	0048471	cellular_component	perinuclear region of cytoplasm
S	1902162	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
S	2000434	biological_process	regulation of protein neddylation
t	0000338	biological_process	protein deneddylation
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0008180	cellular_component	COP9 signalosome
t	0008233	molecular_function	peptidase activity
t	0008237	molecular_function	metallopeptidase activity
t	0045116	biological_process	protein neddylation
t	0048471	cellular_component	perinuclear region of cytoplasm
t	0140492	molecular_function	metal-dependent deubiquitinase activity
t	2000434	biological_process	regulation of protein neddylation
T	0000338	biological_process	protein deneddylation
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0008021	cellular_component	synaptic vesicle
T	0008180	cellular_component	COP9 signalosome
T	0016607	cellular_component	nuclear speck
T	0019784	molecular_function	deNEDDylase activity
T	0030054	cellular_component	cell junction
T	0031410	cellular_component	cytoplasmic vesicle
T	0032991	cellular_component	protein-containing complex
T	0045116	biological_process	protein neddylation
T	0045202	cellular_component	synapse
T	2000434	biological_process	regulation of protein neddylation
u	0008180	cellular_component	COP9 signalosome
u	0010387	biological_process	COP9 signalosome assembly
U	0000338	biological_process	protein deneddylation
U	0000785	cellular_component	chromatin
U	0003713	molecular_function	transcription coactivator activity
U	0003743	molecular_function	translation initiation factor activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
U	0006412	biological_process	translation
U	0006413	biological_process	translational initiation
U	0006508	biological_process	proteolysis
U	0008021	cellular_component	synaptic vesicle
U	0008180	cellular_component	COP9 signalosome
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0019784	molecular_function	deNEDDylase activity
U	0019899	molecular_function	enzyme binding
U	0031410	cellular_component	cytoplasmic vesicle
U	0035718	molecular_function	macrophage migration inhibitory factor binding
U	0043066	biological_process	negative regulation of apoptotic process
U	0043687	biological_process	post-translational protein modification
U	0045116	biological_process	protein neddylation
U	0045202	cellular_component	synapse
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0046328	biological_process	regulation of JNK cascade
U	0046872	molecular_function	metal ion binding
U	0048471	cellular_component	perinuclear region of cytoplasm
U	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
U	0051726	biological_process	regulation of cell cycle
U	0140492	molecular_function	metal-dependent deubiquitinase activity
U	1903894	biological_process	regulation of IRE1-mediated unfolded protein response
U	1990182	biological_process	exosomal secretion
U	2000434	biological_process	regulation of protein neddylation
v	0000338	biological_process	protein deneddylation
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005737	cellular_component	cytoplasm
v	0005829	cellular_component	cytosol
v	0006468	biological_process	protein phosphorylation
v	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
v	0008180	cellular_component	COP9 signalosome
v	0008285	biological_process	negative regulation of cell population proliferation
v	0010387	biological_process	COP9 signalosome assembly
v	0045116	biological_process	protein neddylation
v	0048471	cellular_component	perinuclear region of cytoplasm
v	0070062	cellular_component	extracellular exosome
v	2000434	biological_process	regulation of protein neddylation
V	0000338	biological_process	protein deneddylation
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0008180	cellular_component	COP9 signalosome
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0045116	biological_process	protein neddylation
V	0048471	cellular_component	perinuclear region of cytoplasm
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	2000434	biological_process	regulation of protein neddylation
W	0008180	cellular_component	COP9 signalosome
W	0010387	biological_process	COP9 signalosome assembly
X	0000338	biological_process	protein deneddylation
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006468	biological_process	protein phosphorylation
X	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
X	0008180	cellular_component	COP9 signalosome
X	0008285	biological_process	negative regulation of cell population proliferation
X	0010387	biological_process	COP9 signalosome assembly
X	0045116	biological_process	protein neddylation
X	0048471	cellular_component	perinuclear region of cytoplasm
X	0070062	cellular_component	extracellular exosome
X	2000434	biological_process	regulation of protein neddylation
Y	0000338	biological_process	protein deneddylation
Y	0005095	molecular_function	GTPase inhibitor activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0007254	biological_process	JNK cascade
Y	0008180	cellular_component	COP9 signalosome
Y	0032991	cellular_component	protein-containing complex
Y	0045116	biological_process	protein neddylation
Y	2000434	biological_process	regulation of protein neddylation
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0000338	biological_process	protein deneddylation
Z	0001833	biological_process	inner cell mass cell proliferation
Z	0001834	biological_process	trophectodermal cell proliferation
Z	0003714	molecular_function	transcription corepressor activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0006366	biological_process	transcription by RNA polymerase II
Z	0006468	biological_process	protein phosphorylation
Z	0007165	biological_process	signal transduction
Z	0008180	cellular_component	COP9 signalosome
Z	0030182	biological_process	neuron differentiation
Z	0032991	cellular_component	protein-containing complex
Z	0035914	biological_process	skeletal muscle cell differentiation
Z	0045116	biological_process	protein neddylation
Z	0045892	biological_process	negative regulation of DNA-templated transcription
Z	2000434	biological_process	regulation of protein neddylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN E 401

Chain	Residue
E	GLU104
E	HIS138
E	HIS140
E	ASP151

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN M 401

Chain	Residue
M	GLU104
M	HIS138
M	HIS140
M	ASP151

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN U 401

Chain	Residue
U	HIS138
U	HIS140
U	ASP151
U	GLU104

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN c 401

Chain	Residue
c	GLU104
c	HIS138
c	HIS140
c	ASP151

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN k 401

Chain	Residue
k	GLU104
k	HIS138
k	HIS140
k	ASP151

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN s 401

Chain	Residue
s	GLU104
s	HIS138
s	HIS140
s	ASP151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18850735, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
H	SER175
c	HIS138
c	HIS140
c	ASP151
k	HIS138
k	HIS140
k	ASP151
s	HIS138
s	HIS140
s	ASP151
P	SER175
X	SER175
f	SER175
n	SER175
v	SER175
U	HIS138
U	HIS140
U	ASP151

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
D	LYS25
L	LYS25
T	LYS25
b	LYS25
j	LYS25
r	LYS25

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER410
K	SER410
S	SER410
a	SER410
i	SER410
q	SER410

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18850735, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
C	SER423
K	SER423
S	SER423
a	SER423
i	SER423
q	SER423

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)