4WQO

Structure of VHL-EloB-EloC-Cul2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Von Hippel-Lindau disease tumor suppressor	polymer	233	26352.1	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (Human)	Protein G7,pVHL
2	B (B)	Transcription elongation factor B polypeptide 2	polymer	118	13147.8	1	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	Elongin 18 kDa subunit,Elongin-B,EloB,RNA polymerase II transcription factor SIII subunit B,SIII p18
3	C (C)	Transcription elongation factor B polypeptide 1	polymer	96	10843.4	1	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	Elongin 15 kDa subunit,Elongin-C,EloC,RNA polymerase II transcription factor SIII subunit C,SIII p15
4	D (D)	Cullin-2	polymer	186	22131.5	1	UniProt (Q13617) Pfam (PF00888)	Homo sapiens (Human)	CUL-2

Sequence modifications

A: 1 - 213 (UniProt: P40337)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

D: 1 - 163 (UniProt: Q13617)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Gln -11	-	expression tag
Asp -10	-	expression tag
Pro -9	-	expression tag
Thr -8	-	expression tag
Thr -7	-	expression tag
Val -6	-	expression tag
Lys -5	-	expression tag
Leu -4	-	expression tag
Gln -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	72474.8
All*	Total formula weight	72474.8

*Water molecules are not included.