4WQO

Structure of VHL-EloB-EloC-Cul2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000902	biological_process	cell morphogenesis
A	0001666	biological_process	response to hypoxia
A	0003711	molecular_function	transcription elongation factor activity
A	0003714	molecular_function	transcription corepressor activity
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006508	biological_process	proteolysis
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009968	biological_process	negative regulation of signal transduction
A	0010468	biological_process	regulation of gene expression
A	0010507	biological_process	negative regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0016567	biological_process	protein ubiquitination
A	0019899	molecular_function	enzyme binding
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0043066	biological_process	negative regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045597	biological_process	positive regulation of cell differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046426	biological_process	negative regulation of receptor signaling pathway via JAK-STAT
A	0050821	biological_process	protein stabilization
A	0060090	molecular_function	molecular adaptor activity
A	0071456	biological_process	cellular response to hypoxia
A	0120283	molecular_function	protein serine/threonine kinase binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1900037	biological_process	regulation of cellular response to hypoxia
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990000	biological_process	amyloid fibril formation
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0001222	molecular_function	transcription corepressor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0016567	biological_process	protein ubiquitination
B	0030891	cellular_component	VCB complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0070449	cellular_component	elongin complex
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0140958	biological_process	target-directed miRNA degradation
B	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
B	2000104	biological_process	negative regulation of DNA-templated DNA replication
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0031625	molecular_function	ubiquitin protein ligase binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	55
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	65
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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