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4WQO

Structure of VHL-EloB-EloC-Cul2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000902biological_processcell morphogenesis
A0003711molecular_functiontranscription elongation factor activity
A0003714molecular_functiontranscription corepressor activity
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006508biological_processproteolysis
A0008285biological_processnegative regulation of cell population proliferation
A0009968biological_processnegative regulation of signal transduction
A0010468biological_processregulation of gene expression
A0010507biological_processnegative regulation of autophagy
A0010629biological_processnegative regulation of gene expression
A0016567biological_processprotein ubiquitination
A0019899molecular_functionenzyme binding
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043232cellular_componentintracellular non-membrane-bounded organelle
A0045597biological_processpositive regulation of cell differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046426biological_processnegative regulation of receptor signaling pathway via JAK-STAT
A0050821biological_processprotein stabilization
A0060090molecular_functionmolecular adaptor activity
A0071456biological_processcellular response to hypoxia
A0140297molecular_functionDNA-binding transcription factor binding
A1900037biological_processregulation of cellular response to hypoxia
A1904262biological_processnegative regulation of TORC1 signaling
A1990000biological_processamyloid fibril formation
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B0001222molecular_functiontranscription corepressor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006368biological_processtranscription elongation by RNA polymerase II
B0016567biological_processprotein ubiquitination
B0030891cellular_componentVCB complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0065003biological_processprotein-containing complex assembly
B0070449cellular_componentelongin complex
B0140958biological_processtarget-directed miRNA degradation
C0006511biological_processubiquitin-dependent protein catabolic process
D0006511biological_processubiquitin-dependent protein catabolic process
D0031625molecular_functionubiquitin protein ligase binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
BMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869
ChainResidueDetails
BTHR84

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869
ChainResidueDetails
BSER108
BSER111

221051

PDB entries from 2024-06-12

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