4WJG

Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, K, P, U...	Hemoglobin subunit alpha	polymer	141	15150.4	6	UniProt (P69905) Pfam (PF00042) In PDB	Homo sapiens (Human)	Alpha-globin,Hemoglobin alpha chain
2	B, G, L, Q, V...	Hemoglobin subunit beta	polymer	146	15890.2	6	UniProt (P68871) Pfam (PF00042) In PDB	Homo sapiens (Human)	Beta-globin,Hemoglobin beta chain
3	C, H, M, R, W...	Haptoglobin	polymer	315	35267.1	6	UniProt (P00738) Pfam (PF00089) In PDB	Homo sapiens (Human)	Zonulin
4	D, I, N, S, X...	Iron-regulated surface determinant protein H	polymer	146	16877.6	6	UniProt (Q99TD3) Pfam (PF05031) In PDB	Staphylococcus aureus subsp. aureus N315	Haptoglobin receptor A,Staphylococcus aureus surface protein I
5	E, J, O, T, Y...	Haptoglobin-hemoglobin receptor	polymer	343	36848.6	6	UniProt (I7BA80) Pfam (PF20933) In PDB	Trypanosoma brucei brucei
6	a, b, c, d, e...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	10	In PDB GlyTouCan (G42666HT)	Trypanosoma brucei brucei
7	Z, K, 1, L, P...	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	12	Chemie (HEM)	Homo sapiens (Human)
8	Z, K, 1, L, P...	OXYGEN MOLECULE	non-polymer		32.0	12	Chemie (OXY)	Homo sapiens (Human)
9	H, Y, J, 2, 4...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	23	Chemie (NAG)	Trypanosoma brucei brucei

Sequence modifications

D, I, N, S, X, 3: 86 - 229 (UniProt: Q99TD3)

PDB	External Database	Details
Gly 84	-	expression tag
Ser 85	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	30
	Total formula weight	720203.1
Branched	Number of molecules	10
	Total formula weight	4244.0
Non-Polymers*	Number of molecules	47
	Total formula weight	12869.6
All*	Total formula weight	737316.7

*Water molecules are not included.