4WJG

Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004601	molecular_function	peroxidase activity
1	0005344	molecular_function	oxygen carrier activity
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005615	cellular_component	extracellular space
1	0005829	cellular_component	cytosol
1	0005833	cellular_component	hemoglobin complex
1	0008217	biological_process	regulation of blood pressure
1	0015670	biological_process	carbon dioxide transport
1	0015671	biological_process	oxygen transport
1	0019825	molecular_function	oxygen binding
1	0020037	molecular_function	heme binding
1	0030185	biological_process	nitric oxide transport
1	0030492	molecular_function	hemoglobin binding
1	0031720	molecular_function	haptoglobin binding
1	0031721	molecular_function	hemoglobin alpha binding
1	0031838	cellular_component	haptoglobin-hemoglobin complex
1	0042542	biological_process	response to hydrogen peroxide
1	0042744	biological_process	hydrogen peroxide catabolic process
1	0043177	molecular_function	organic acid binding
1	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
1	0046872	molecular_function	metal ion binding
1	0070062	cellular_component	extracellular exosome
1	0070293	biological_process	renal absorption
1	0070527	biological_process	platelet aggregation
1	0071682	cellular_component	endocytic vesicle lumen
1	0072562	cellular_component	blood microparticle
1	0097746	biological_process	blood vessel diameter maintenance
1	0098869	biological_process	cellular oxidant detoxification
1	1904724	cellular_component	tertiary granule lumen
1	1904813	cellular_component	ficolin-1-rich granule lumen
2	0004252	molecular_function	serine-type endopeptidase activity
2	0005576	cellular_component	extracellular region
2	0006508	biological_process	proteolysis
2	0030492	molecular_function	hemoglobin binding
4	0046872	molecular_function	metal ion binding
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0008217	biological_process	regulation of blood pressure
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0030492	molecular_function	hemoglobin binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070293	biological_process	renal absorption
B	0070527	biological_process	platelet aggregation
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0097746	biological_process	blood vessel diameter maintenance
B	0098869	biological_process	cellular oxidant detoxification
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0030492	molecular_function	hemoglobin binding
E	0046872	molecular_function	metal ion binding
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005829	cellular_component	cytosol
F	0005833	cellular_component	hemoglobin complex
F	0015670	biological_process	carbon dioxide transport
F	0015671	biological_process	oxygen transport
F	0016020	cellular_component	membrane
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0030185	biological_process	nitric oxide transport
F	0031720	molecular_function	haptoglobin binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042542	biological_process	response to hydrogen peroxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0043177	molecular_function	organic acid binding
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071682	cellular_component	endocytic vesicle lumen
F	0072562	cellular_component	blood microparticle
F	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005829	cellular_component	cytosol
G	0005833	cellular_component	hemoglobin complex
G	0008217	biological_process	regulation of blood pressure
G	0015670	biological_process	carbon dioxide transport
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0030185	biological_process	nitric oxide transport
G	0030492	molecular_function	hemoglobin binding
G	0031720	molecular_function	haptoglobin binding
G	0031721	molecular_function	hemoglobin alpha binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042542	biological_process	response to hydrogen peroxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0070293	biological_process	renal absorption
G	0070527	biological_process	platelet aggregation
G	0071682	cellular_component	endocytic vesicle lumen
G	0072562	cellular_component	blood microparticle
G	0097746	biological_process	blood vessel diameter maintenance
G	0098869	biological_process	cellular oxidant detoxification
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005576	cellular_component	extracellular region
H	0006508	biological_process	proteolysis
H	0030492	molecular_function	hemoglobin binding
J	0046872	molecular_function	metal ion binding
K	0004601	molecular_function	peroxidase activity
K	0005344	molecular_function	oxygen carrier activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005829	cellular_component	cytosol
K	0005833	cellular_component	hemoglobin complex
K	0015670	biological_process	carbon dioxide transport
K	0015671	biological_process	oxygen transport
K	0016020	cellular_component	membrane
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0030185	biological_process	nitric oxide transport
K	0031720	molecular_function	haptoglobin binding
K	0031838	cellular_component	haptoglobin-hemoglobin complex
K	0042542	biological_process	response to hydrogen peroxide
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0043177	molecular_function	organic acid binding
K	0046872	molecular_function	metal ion binding
K	0070062	cellular_component	extracellular exosome
K	0071682	cellular_component	endocytic vesicle lumen
K	0072562	cellular_component	blood microparticle
K	0098869	biological_process	cellular oxidant detoxification
L	0004601	molecular_function	peroxidase activity
L	0005344	molecular_function	oxygen carrier activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005829	cellular_component	cytosol
L	0005833	cellular_component	hemoglobin complex
L	0008217	biological_process	regulation of blood pressure
L	0015670	biological_process	carbon dioxide transport
L	0015671	biological_process	oxygen transport
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0030185	biological_process	nitric oxide transport
L	0030492	molecular_function	hemoglobin binding
L	0031720	molecular_function	haptoglobin binding
L	0031721	molecular_function	hemoglobin alpha binding
L	0031838	cellular_component	haptoglobin-hemoglobin complex
L	0042542	biological_process	response to hydrogen peroxide
L	0042744	biological_process	hydrogen peroxide catabolic process
L	0043177	molecular_function	organic acid binding
L	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	0070293	biological_process	renal absorption
L	0070527	biological_process	platelet aggregation
L	0071682	cellular_component	endocytic vesicle lumen
L	0072562	cellular_component	blood microparticle
L	0097746	biological_process	blood vessel diameter maintenance
L	0098869	biological_process	cellular oxidant detoxification
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005576	cellular_component	extracellular region
M	0006508	biological_process	proteolysis
M	0030492	molecular_function	hemoglobin binding
O	0046872	molecular_function	metal ion binding
P	0004601	molecular_function	peroxidase activity
P	0005344	molecular_function	oxygen carrier activity
P	0005506	molecular_function	iron ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005829	cellular_component	cytosol
P	0005833	cellular_component	hemoglobin complex
P	0015670	biological_process	carbon dioxide transport
P	0015671	biological_process	oxygen transport
P	0016020	cellular_component	membrane
P	0019825	molecular_function	oxygen binding
P	0020037	molecular_function	heme binding
P	0030185	biological_process	nitric oxide transport
P	0031720	molecular_function	haptoglobin binding
P	0031838	cellular_component	haptoglobin-hemoglobin complex
P	0042542	biological_process	response to hydrogen peroxide
P	0042744	biological_process	hydrogen peroxide catabolic process
P	0043177	molecular_function	organic acid binding
P	0046872	molecular_function	metal ion binding
P	0070062	cellular_component	extracellular exosome
P	0071682	cellular_component	endocytic vesicle lumen
P	0072562	cellular_component	blood microparticle
P	0098869	biological_process	cellular oxidant detoxification
Q	0004601	molecular_function	peroxidase activity
Q	0005344	molecular_function	oxygen carrier activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005829	cellular_component	cytosol
Q	0005833	cellular_component	hemoglobin complex
Q	0008217	biological_process	regulation of blood pressure
Q	0015670	biological_process	carbon dioxide transport
Q	0015671	biological_process	oxygen transport
Q	0019825	molecular_function	oxygen binding
Q	0020037	molecular_function	heme binding
Q	0030185	biological_process	nitric oxide transport
Q	0030492	molecular_function	hemoglobin binding
Q	0031720	molecular_function	haptoglobin binding
Q	0031721	molecular_function	hemoglobin alpha binding
Q	0031838	cellular_component	haptoglobin-hemoglobin complex
Q	0042542	biological_process	response to hydrogen peroxide
Q	0042744	biological_process	hydrogen peroxide catabolic process
Q	0043177	molecular_function	organic acid binding
Q	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
Q	0046872	molecular_function	metal ion binding
Q	0070062	cellular_component	extracellular exosome
Q	0070293	biological_process	renal absorption
Q	0070527	biological_process	platelet aggregation
Q	0071682	cellular_component	endocytic vesicle lumen
Q	0072562	cellular_component	blood microparticle
Q	0097746	biological_process	blood vessel diameter maintenance
Q	0098869	biological_process	cellular oxidant detoxification
Q	1904724	cellular_component	tertiary granule lumen
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005576	cellular_component	extracellular region
R	0006508	biological_process	proteolysis
R	0030492	molecular_function	hemoglobin binding
T	0046872	molecular_function	metal ion binding
U	0004601	molecular_function	peroxidase activity
U	0005344	molecular_function	oxygen carrier activity
U	0005506	molecular_function	iron ion binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005829	cellular_component	cytosol
U	0005833	cellular_component	hemoglobin complex
U	0015670	biological_process	carbon dioxide transport
U	0015671	biological_process	oxygen transport
U	0016020	cellular_component	membrane
U	0019825	molecular_function	oxygen binding
U	0020037	molecular_function	heme binding
U	0030185	biological_process	nitric oxide transport
U	0031720	molecular_function	haptoglobin binding
U	0031838	cellular_component	haptoglobin-hemoglobin complex
U	0042542	biological_process	response to hydrogen peroxide
U	0042744	biological_process	hydrogen peroxide catabolic process
U	0043177	molecular_function	organic acid binding
U	0046872	molecular_function	metal ion binding
U	0070062	cellular_component	extracellular exosome
U	0071682	cellular_component	endocytic vesicle lumen
U	0072562	cellular_component	blood microparticle
U	0098869	biological_process	cellular oxidant detoxification
V	0004601	molecular_function	peroxidase activity
V	0005344	molecular_function	oxygen carrier activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005615	cellular_component	extracellular space
V	0005829	cellular_component	cytosol
V	0005833	cellular_component	hemoglobin complex
V	0008217	biological_process	regulation of blood pressure
V	0015670	biological_process	carbon dioxide transport
V	0015671	biological_process	oxygen transport
V	0019825	molecular_function	oxygen binding
V	0020037	molecular_function	heme binding
V	0030185	biological_process	nitric oxide transport
V	0030492	molecular_function	hemoglobin binding
V	0031720	molecular_function	haptoglobin binding
V	0031721	molecular_function	hemoglobin alpha binding
V	0031838	cellular_component	haptoglobin-hemoglobin complex
V	0042542	biological_process	response to hydrogen peroxide
V	0042744	biological_process	hydrogen peroxide catabolic process
V	0043177	molecular_function	organic acid binding
V	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
V	0046872	molecular_function	metal ion binding
V	0070062	cellular_component	extracellular exosome
V	0070293	biological_process	renal absorption
V	0070527	biological_process	platelet aggregation
V	0071682	cellular_component	endocytic vesicle lumen
V	0072562	cellular_component	blood microparticle
V	0097746	biological_process	blood vessel diameter maintenance
V	0098869	biological_process	cellular oxidant detoxification
V	1904724	cellular_component	tertiary granule lumen
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0004252	molecular_function	serine-type endopeptidase activity
W	0005576	cellular_component	extracellular region
W	0006508	biological_process	proteolysis
W	0030492	molecular_function	hemoglobin binding
Y	0046872	molecular_function	metal ion binding
Z	0004601	molecular_function	peroxidase activity
Z	0005344	molecular_function	oxygen carrier activity
Z	0005506	molecular_function	iron ion binding
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0005829	cellular_component	cytosol
Z	0005833	cellular_component	hemoglobin complex
Z	0015670	biological_process	carbon dioxide transport
Z	0015671	biological_process	oxygen transport
Z	0016020	cellular_component	membrane
Z	0019825	molecular_function	oxygen binding
Z	0020037	molecular_function	heme binding
Z	0030185	biological_process	nitric oxide transport
Z	0031720	molecular_function	haptoglobin binding
Z	0031838	cellular_component	haptoglobin-hemoglobin complex
Z	0042542	biological_process	response to hydrogen peroxide
Z	0042744	biological_process	hydrogen peroxide catabolic process
Z	0043177	molecular_function	organic acid binding
Z	0046872	molecular_function	metal ion binding
Z	0070062	cellular_component	extracellular exosome
Z	0071682	cellular_component	endocytic vesicle lumen
Z	0072562	cellular_component	blood microparticle
Z	0098869	biological_process	cellular oxidant detoxification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218

Chain	Residue	Details
C	ASN180
L	HIS2
L	LYS82
L	HIS143
Q	VAL1
Q	HIS2
Q	LYS82
Q	HIS143
V	VAL1
V	HIS2
V	LYS82
H	ASN180
V	HIS143
1	VAL1
1	HIS2
1	LYS82
1	HIS143
M	ASN180
R	ASN180
W	ASN180
2	ASN180
G	LYS82
G	HIS143
L	VAL1

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218

Chain	Residue	Details
C	ASN203
H	ASN203
M	ASN203
R	ASN203
W	ASN203
2	ASN203

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218

Chain	Residue	Details
C	ASN207
A	LEU91
A	LEU106
A	THR108
A	VAL121
A	SER133
F	THR8
F	ALA13
F	TYR24
F	LEU29
F	HIS45
H	ASN207
F	ASP47
F	SER52
F	VAL55
F	GLY59
F	LEU91
F	LEU106
F	THR108
F	VAL121
F	SER133
K	THR8
M	ASN207
K	ALA13
K	TYR24
K	LEU29
K	HIS45
K	ASP47
K	SER52
K	VAL55
K	GLY59
K	LEU91
K	LEU106
R	ASN207
K	THR108
K	VAL121
K	SER133
P	THR8
P	ALA13
P	TYR24
P	LEU29
P	HIS45
P	ASP47
P	SER52
W	ASN207
P	VAL55
P	GLY59
P	LEU91
P	LEU106
P	THR108
P	VAL121
P	SER133
U	THR8
U	ALA13
U	TYR24
2	ASN207
U	LEU29
U	HIS45
U	ASP47
U	SER52
U	VAL55
U	GLY59
U	LEU91
U	LEU106
U	THR108
U	VAL121
A	SER52
U	SER133
Z	THR8
Z	ALA13
Z	TYR24
Z	LEU29
Z	HIS45
Z	ASP47
Z	SER52
Z	VAL55
Z	GLY59
A	VAL55
Z	LEU91
Z	LEU106
Z	THR108
Z	VAL121
Z	SER133
A	GLY59

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169

Chain	Residue	Details
C	ASN237
B	GLY74
1	TRP37
1	PHE45
1	ASP52
1	GLY56
1	PHE71
1	GLY74
1	THR84
1	HIS92
1	ARG104
1	LEU110
B	THR84
1	GLY119
1	PHE122
1	ALA128
1	ALA140
1	LYS144
B	HIS92
B	ARG104
B	LEU110
B	GLY119
B	PHE122
B	ALA128
B	ALA140
B	LYS144
H	ASN237
G	GLU7
G	GLY25
G	GLY29
G	TYR35
G	TRP37
G	PHE45
G	ASP52
G	GLY56
G	PHE71
G	GLY74
M	ASN237
G	THR84
G	HIS92
G	ARG104
G	LEU110
G	GLY119
G	PHE122
G	ALA128
G	ALA140
G	LYS144
L	GLU7
R	ASN237
L	GLY25
L	GLY29
L	TYR35
L	TRP37
L	PHE45
L	ASP52
L	GLY56
L	PHE71
L	GLY74
L	THR84
W	ASN237
L	HIS92
L	ARG104
L	LEU110
L	GLY119
L	PHE122
L	ALA128
L	ALA140
L	LYS144
Q	GLU7
Q	GLY25
2	ASN237
Q	GLY29
Q	TYR35
Q	TRP37
Q	PHE45
Q	ASP52
Q	GLY56
Q	PHE71
Q	GLY74
Q	THR84
Q	HIS92
B	ASP52
Q	ARG104
Q	LEU110
Q	GLY119
Q	PHE122
Q	ALA128
Q	ALA140
Q	LYS144
V	GLU7
V	GLY25
V	GLY29
B	GLY56
V	TYR35
V	TRP37
V	PHE45
V	ASP52
V	GLY56
V	PHE71
V	GLY74
V	THR84
V	HIS92
V	ARG104
B	PHE71
V	LEU110
V	GLY119
V	PHE122
V	ALA128
V	ALA140
V	LYS144
1	GLU7
1	GLY25
1	GLY29
1	TYR35

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	SITE: Not glycated => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS59
Q	LYS59
Q	LYS82
Q	LYS95
V	LYS59
V	LYS82
V	LYS95
1	LYS59
1	LYS82
1	LYS95
B	LYS82
B	LYS95
G	LYS59
G	LYS82
G	LYS95
L	LYS59
L	LYS82
L	LYS95

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b

Chain	Residue	Details
B	VAL1
P	LYS7
P	LYS16
P	LYS40
U	LYS7
U	LYS16
U	LYS40
Z	LYS7
Z	LYS16
Z	LYS40
G	VAL1
L	VAL1
Q	VAL1
V	VAL1
1	VAL1
K	LYS7
K	LYS16
K	LYS40

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER9
V	SER44
1	SER9
1	SER44
B	SER44
G	SER9
G	SER44
L	SER9
L	SER44
Q	SER9
Q	SER44
V	SER9

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	THR12
Q	THR12
Q	THR50
Q	THR87
V	THR12
V	THR50
V	THR87
1	THR12
1	THR50
1	THR87
B	THR50
B	THR87
G	THR12
G	THR50
G	THR87
L	THR12
L	THR50
L	THR87

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009

Chain	Residue	Details
B	LYS59
V	LYS82
1	LYS59
1	LYS82
B	LYS82
G	LYS59
G	LYS82
L	LYS59
L	LYS82
Q	LYS59
Q	LYS82
V	LYS59

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411

Chain	Residue	Details
B	CYS93
K	SER124
K	SER131
K	SER138
P	SER102
P	SER124
P	SER131
P	SER138
U	SER102
U	SER124
U	SER131
G	CYS93
U	SER138
Z	SER102
Z	SER124
Z	SER131
Z	SER138
L	CYS93
Q	CYS93
V	CYS93
1	CYS93
F	SER131
F	SER138
K	SER102

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009

Chain	Residue	Details
B	LYS144
P	THR108
P	THR134
P	THR137
U	THR108
U	THR134
U	THR137
Z	THR108
Z	THR134
Z	THR137
G	LYS144
L	LYS144
Q	LYS144
V	LYS144
1	LYS144
K	THR108
K	THR134
K	THR137

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569

Chain	Residue	Details
B	VAL1
P	LYS7
P	LYS16
P	LYS40
U	LYS7
U	LYS16
U	LYS40
Z	LYS7
Z	LYS16
Z	LYS40
G	VAL1
L	VAL1
Q	VAL1
V	VAL1
1	VAL1
K	LYS7
K	LYS16
K	LYS40

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS8
L	LYS17
L	LYS66
L	LYS120
Q	LYS8
Q	LYS17
Q	LYS66
Q	LYS120
V	LYS8
V	LYS17
V	LYS66
B	LYS17
V	LYS120
1	LYS8
1	LYS17
1	LYS66
1	LYS120
B	LYS66
B	LYS120
G	LYS8
G	LYS17
G	LYS66
G	LYS120
L	LYS8

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS144
G	LYS144
L	LYS144
Q	LYS144
V	LYS144
1	LYS144

---