4W4O
High-resolution crystal structure of Fc bound to its human receptor Fc-gamma-RI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Ig gamma-1 chain C region | polymer | 224 | 25219.6 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 2 | C | High affinity immunoglobulin gamma Fc receptor I | polymer | 280 | 31554.6 | 1 | UniProt (P12314) Pfam (PF13927) Pfam (PF13895) Pfam (PF00047) In PDB | Homo sapiens (Human) | IgG Fc receptor I, Fc-gamma RI, FcRI, Fc-gamma RIA, FcgammaRIa |
| 3 | D, E | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G27919IH) | |||
| 4 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G01760ZU) | |||
| 6 | A, B, C | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 7 | A, B, C | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
| 8 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | water | water | 18.0 | 566 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 447 (UniProt: P01857)
C: 16 - 289 (UniProt: P12314)
| PDB | External Database | Details |
|---|---|---|
| Ala 444 | Ser 327 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 20 | Thr 20 | engineered mutation |
| Lys 25 | Thr 25 | engineered mutation |
| Ser 38 | Thr 38 | engineered mutation |
| Pro 46 | Leu 46 | engineered mutation |
| Ile 63 | Thr 63 | engineered mutation |
| Thr 69 | Ser 69 | engineered mutation |
| His 71 | Arg 71 | engineered mutation |
| Glu 77 | Val 77 | engineered mutation |
| Asp 78 | Asn 78 | engineered mutation |
| Val 100 | Ile 100 | engineered mutation |
| Leu 114 | Phe 114 | engineered mutation |
| Met 160 | Ile 160 | engineered mutation |
| Ser 163 | Asn 163 | engineered mutation |
| Thr 195 | Asn 195 | engineered mutation |
| Thr 206 | Asn 206 | engineered mutation |
| Pro 207 | Leu 207 | engineered mutation |
| Asp 240 | Asn 240 | engineered mutation |
| His 283 | Leu 283 | engineered mutation |
| Gln 285 | Leu 285 | engineered mutation |
| His 290 | - | expression tag |
| His 291 | - | expression tag |
| His 292 | - | expression tag |
| His 293 | - | expression tag |
| His 294 | - | expression tag |
| His 295 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 81993.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4748.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1108.0 | |
| All* | Total formula weight | 87850.2 |
