4UWB
Fibroblast growth factor receptor 1 kinase in complex with JK-P5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FIBROBLAST GROWTH FACTOR RECEPTOR 1 | polymer | 309 | 35135.3 | 2 | UniProt (P11362) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, BFGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE |
| 2 | C, D, E, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | F, J (A, B) | N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-3-carboxamide | non-polymer | 335.4 | 2 | Chemie (JVT) | |||
| 4 | G, K (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 457 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70270.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1173.3 | |
| All* | Total formula weight | 71444.0 |
