4U7P
Crystal structure of DNMT3A-DNMT3L complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA (cytosine-5)-methyltransferase 3A | polymer | 466 | 53350.4 | 1 | UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (Human) | DNA methyltransferases DNMT3A |
| 2 | B (B) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24119.7 | 1 | UniProt (Q9UJW3) | Homo sapiens (Human) | DNA methyltransferases DNMT3L |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
A: 455 - 912 (UniProt: Q9Y6K1)
B: 178 - 379 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 447 | - | expression tag |
| Pro 448 | - | expression tag |
| Leu 449 | - | expression tag |
| Gly 450 | - | expression tag |
| Ser 451 | - | expression tag |
| Pro 452 | - | expression tag |
| Glu 453 | - | expression tag |
| Phe 454 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Leu 173 | - | expression tag |
| Gly 174 | - | expression tag |
| Ser 175 | - | expression tag |
| Glu 176 | - | expression tag |
| Phe 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77470.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 580.6 | |
| All* | Total formula weight | 78050.6 |
