4U7P
Crystal structure of DNMT3A-DNMT3L complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA (cytosine-5)-methyltransferase 3A | polymer | 466 | 53350.4 | 1 | UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (Human) | DNA methyltransferases DNMT3A |
| 2 | B (B) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24119.7 | 1 | UniProt (Q9UJW3) | Homo sapiens (Human) | DNA methyltransferases DNMT3L |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
A: 455 - 912 (UniProt: Q9Y6K1)
B: 178 - 379 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 447 | - | expression tag |
| Pro 448 | - | expression tag |
| Leu 449 | - | expression tag |
| Gly 450 | - | expression tag |
| Ser 451 | - | expression tag |
| Pro 452 | - | expression tag |
| Glu 453 | - | expression tag |
| Phe 454 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Leu 173 | - | expression tag |
| Gly 174 | - | expression tag |
| Ser 175 | - | expression tag |
| Glu 176 | - | expression tag |
| Phe 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77470.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 580.6 | |
| All* | Total formula weight | 78050.6 |
