4RSC
Crystal structure of RPE65 in complex with emixustat and palmitate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Retinoid isomerohydrolase | polymer | 533 | 61040.2 | 2 | UniProt (Q28175) Pfam (PF03055) | Bos taurus (bovine cow domestic cattle domestic cow) | All-trans-retinyl-palmitate hydrolase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase |
| 2 | C, F (A, B) | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) | |||
| 3 | D, G (A, B) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
| 4 | E, H (A, B) | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol | non-polymer | 263.4 | 2 | Chemie (A3V) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 1004 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 533 (UniProt: Q28175)
| PDB | External Database | Details |
|---|---|---|
| Leu 341 | Ser 341 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122080.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1151.3 | |
| All* | Total formula weight | 123231.7 |
