4RQX

Crystal structure of human peroxiredoxin 4(THIOREDOXIN PEROXIDASE) with MESNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (A, B, C, D, E)	Peroxiredoxin-4	polymer	226	25456.8	5	UniProt (Q13162) Pfam (PF00578) Pfam (PF10417)	Homo sapiens (human)	Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372
2	F, G, H, I, J (A, B, C, D, E)	1-THIOETHANESULFONIC ACID	non-polymer		142.2	5	Chemie (COM)
3	K, L, M, N, O (A, B, C, D, E)	water	water		18.0	191	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 79 - 271 (UniProt: Q13162)

PDB	External Database	Details
Met 46	-	expression tag
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag
Thr 67	-	expression tag
Thr 68	-	expression tag
Glu 69	-	expression tag
Asn 70	-	expression tag
Leu 71	-	expression tag
Tyr 72	-	expression tag
Phe 73	-	expression tag
Gln 74	-	expression tag
Gly 75	-	expression tag
Ala 76	-	expression tag
Gly 77	-	expression tag
Thr 78	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	127284.2
Non-Polymers*	Number of molecules	5
	Total formula weight	711.0
All*	Total formula weight	127995.2

*Water molecules are not included.