4RQX
Crystal structure of human peroxiredoxin 4(THIOREDOXIN PEROXIDASE) with MESNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0051920 | molecular_function | peroxiredoxin activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0051920 | molecular_function | peroxiredoxin activity |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0051920 | molecular_function | peroxiredoxin activity |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0051920 | molecular_function | peroxiredoxin activity |
| E | 0016209 | molecular_function | antioxidant activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0051920 | molecular_function | peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE COM A 301 |
| Chain | Residue |
| A | CYS124 |
| A | ARG164 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE COM B 301 |
| Chain | Residue |
| B | VAL123 |
| B | CYS124 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE COM C 301 |
| Chain | Residue |
| C | CYS124 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE COM D 301 |
| Chain | Residue |
| D | CYS124 |
| D | ARG164 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE COM E 301 |
| Chain | Residue |
| E | CYS124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 790 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"12059788","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21916849","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
