4RPP
crystal structure of PKM2-K422R mutant bound with FBP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Pyruvate kinase PKM | polymer | 535 | 58399.3 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (human) | Pyruvate kinase muscle isozyme,Threonine-protein kinase PKM2Tumor M2-PK,Tyrosine-protein kinase PKM2 |
| 2 | A, B, C, D | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
| 3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 422 | Lys 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 233597.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1360.5 | |
| All* | Total formula weight | 234957.6 |
