4RPI

Crystal Structure of Nicotinate Mononucleotide Adenylyltransferase from Mycobacterium tuberculosis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	nicotinate-nucleotide adenylyltransferase	polymer	223	24187.3	4	UniProt (W6GSY1) Pfam (PF01467) UniProt (by SIFTS) (P9WJJ5)	Mycobacterium tuberculosis	Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase
2	E, I, L, M (A, C, D)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	4	Chemie (EPE)
3	F, G, H, J, K... (A, B, C, D)	DIMETHYL SULFOXIDE	non-polymer		78.1	7	Chemie (DMS)
4	P, Q, R, S (A, B, C, D)	water	water		18.0	168	Chemie (HOH)

Sequence modifications

A, B, C, D: 9 - 219 (UniProt: W6GSY1)

PDB	External Database	Details
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Met 1	-	expression tag
His 2	-	expression tag
Gly 3	-	expression tag
Arg 4	-	expression tag
Arg 5	-	expression tag
Leu 6	-	expression tag
Gly 7	-	expression tag
Val 8	-	expression tag
Ala 117	Trp 109	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96749.4
Non-Polymers*	Number of molecules	11
	Total formula weight	1500.2
All*	Total formula weight	98249.5

*Water molecules are not included.