4R2C
Egr1/Zif268 zinc fingers in complex with hydroxymethylated DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Early growth response protein 1 | polymer | 94 | 11133.8 | 1 | UniProt (P18146) Pfam (PF00096) | Homo sapiens (human) | EGR-1, AT225, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24 |
| 2 | B (B) | DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5HC)P*GP*T)-3') | polymer | 11 | 3460.3 | 1 | synthetic construct | ||
| 3 | C (C) | DNA (5'-D(*TP*AP*(5HC)P*GP*CP*CP*CP*AP*CP*GP*C)-3') | polymer | 11 | 3309.2 | 1 | synthetic construct | ||
| 4 | D, E, F (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | G (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | H, I, J (A, B, C) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 335 - 423 (UniProt: P18146)
| PDB | External Database | Details |
|---|---|---|
| Gly 330 | - | expression tag |
| Pro 331 | - | expression tag |
| Leu 332 | - | expression tag |
| Gly 333 | - | expression tag |
| Ser 334 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 17903.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 235.3 | |
| All* | Total formula weight | 18138.5 |
