4R2C
Egr1/Zif268 zinc fingers in complex with hydroxymethylated DNA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS340 |
| A | CYS345 |
| A | HIS358 |
| A | HIS362 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | CYS370 |
| A | CYS373 |
| A | HIS386 |
| A | HIS390 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 503 |
| Chain | Residue |
| A | CYS401 |
| A | HIS414 |
| A | HIS418 |
| A | CYS398 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 504 |
| Chain | Residue |
| A | CYS340 |
| A | VAL342 |
| A | CYS345 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 23 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CpvesCdrrFsrsdeltrHiri..H |
| Chain | Residue | Details |
| A | CYS340-HIS362 | |
| A | CYS370-HIS390 | |
| A | CYS398-HIS418 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Zinc finger: {"description":"C2H2-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25258363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25999311","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X9J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25258363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25999311","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X9J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25258363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25999311","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X9J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"25258363","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"UniProtKB","id":"P08046","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"25999311","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X9J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"25258363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25999311","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X9J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
