4QUN

Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 3	polymer	306	34931.7	2	UniProt (P26045) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase H1, PTP-H1
2	C, D (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	E (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	338	Chemie (HOH)

Sequence modifications

A, B: 628 - 909 (UniProt: P26045)

PDB	External Database	Details
Met 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag
His 607	-	expression tag
His 608	-	expression tag
His 609	-	expression tag
His 610	-	expression tag
Ser 611	-	expression tag
Ser 612	-	expression tag
Gly 613	-	expression tag
Val 614	-	expression tag
Asp 615	-	expression tag
Leu 616	-	expression tag
Gly 617	-	expression tag
Thr 618	-	expression tag
Glu 619	-	expression tag
Asn 620	-	expression tag
Leu 621	-	expression tag
Tyr 622	-	expression tag
Phe 623	-	expression tag
Gln 624	-	expression tag
Ser 625	-	expression tag
Asn 626	-	expression tag
Ala 627	-	expression tag
Ser 842	Cys 842	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69863.3
Non-Polymers*	Number of molecules	3
	Total formula weight	282.0
All*	Total formula weight	70145.4

*Water molecules are not included.