4QUN
Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1001 |
| Chain | Residue |
| A | ASP811 |
| A | HOH1102 |
| A | SER842 |
| A | SER843 |
| A | ALA844 |
| A | GLY845 |
| A | ILE846 |
| A | GLY847 |
| A | ARG848 |
| A | GLN886 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1001 |
| Chain | Residue |
| B | ASP811 |
| B | SER842 |
| B | SER843 |
| B | ALA844 |
| B | GLY845 |
| B | ILE846 |
| B | GLY847 |
| B | ARG848 |
| B | GLN886 |
| B | GOL1002 |
| B | HOH1101 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1002 |
| Chain | Residue |
| B | TYR676 |
| B | ASP811 |
| B | HIS812 |
| B | ALA844 |
| B | GLN886 |
| B | PO41001 |
| B | HOH1231 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 510 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
