4QKX
Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-2 adrenergic receptor | polymer | 469 | 53436.0 | 1 | UniProt (D9IEF7) UniProt (P07550) Pfam (PF00959) Pfam (PF00001) UniProt (by SIFTS) (P00720) In PDB | Enterobacteria phage T4 | Beta-2 adrenoreceptor, Beta-2 adrenoceptor |
2 | B | R9 protein | polymer | 120 | 12949.4 | 1 | Lama glama (Llama) | ||
3 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
4 | A | 4-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(2-sulfanylethoxy)phenyl]ethyl}amino)ethyl]benzene-1,2-diol | non-polymer | 379.5 | 1 | Chemie (35V) |
Sequence modifications
A: 867 - 1026 (UniProt: D9IEF7)
A: 1029 - 1348 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp 852 | - | expression tag |
Tyr 853 | - | expression tag |
Lys 854 | - | expression tag |
Asp 855 | - | expression tag |
Asp 856 | - | expression tag |
Asp 857 | - | expression tag |
Asp 858 | - | expression tag |
Ala 859 | - | expression tag |
Glu 860 | - | expression tag |
Asn 861 | - | expression tag |
Leu 862 | - | expression tag |
Tyr 863 | - | expression tag |
Phe 864 | - | expression tag |
Gln 865 | - | expression tag |
Gly 866 | - | expression tag |
Thr 919 | Cys 54 | engineered mutation |
Ala 962 | Cys 97 | engineered mutation |
Ala 1027 | - | linker |
Ala 1028 | - | linker |
PDB | External Database | Details |
---|---|---|
Cys 1093 | His 93 | engineered mutation |
Thr 1096 | Met 96 | engineered mutation |
Thr 1098 | Met 98 | engineered mutation |
Glu 1187 | Asn 187 | engineered mutation |
- | Lys 235 | deletion |
- | Ser 236 | deletion |
- | Glu 237 | deletion |
- | Gly 238 | deletion |
- | Arg 239 | deletion |
- | Phe 240 | deletion |
- | His 241 | deletion |
- | Val 242 | deletion |
- | Gln 243 | deletion |
- | Asn 244 | deletion |
- | Leu 245 | deletion |
- | Ser 246 | deletion |
- | Gln 247 | deletion |
- | Val 248 | deletion |
- | Glu 249 | deletion |
- | Gln 250 | deletion |
- | Asp 251 | deletion |
- | Gly 252 | deletion |
- | Arg 253 | deletion |
- | Thr 254 | deletion |
- | Gly 255 | deletion |
- | His 256 | deletion |
- | Gly 257 | deletion |
- | Leu 258 | deletion |
- | Arg 259 | deletion |
- | Arg 260 | deletion |
- | Ser 261 | deletion |
- | Ser 262 | deletion |
Ala 1265 | Cys 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66385.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 425.5 | |
All* | Total formula weight | 66810.9 |