4QIL

Crystal structure of the ROQ domain of human Roquin in complex with the Hmg19 stem-loop RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Roquin-1	polymer	330	37214.4	2	UniProt (Q5TC82) Pfam (PF21206) Pfam (PF18386) In PDB	Homo sapiens (human)	Roquin, RING finger and C3H zinc finger protein 1, RING finger and CCCH-type zinc finger domain-containing protein 1, RING finger protein 198
2	D, C	5'-R(*CP*UP*CP*CP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*GP*GP*GP*A)-3'	polymer	19	6070.6	2
3	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4		water	water		18.0	8	Chemie (HOH)

Sequence modifications

A, B: 88 - 407 (UniProt: Q5TC82)

PDB	External Database	Details
Met 86	-	expression tag
Ala 87	-	expression tag
Leu 408	-	expression tag
Glu 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	86570.1
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	86650.3

*Water molecules are not included.