4QIL
Crystal structure of the ROQ domain of human Roquin in complex with the Hmg19 stem-loop RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003730 | molecular_function | mRNA 3'-UTR binding |
| A | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| A | 0042129 | biological_process | regulation of T cell proliferation |
| A | 0050863 | biological_process | regulation of T cell activation |
| B | 0003730 | molecular_function | mRNA 3'-UTR binding |
| B | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| B | 0042129 | biological_process | regulation of T cell proliferation |
| B | 0050863 | biological_process | regulation of T cell activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 501 |
| Chain | Residue |
| A | GLU262 |
| A | ASP393 |
| A | HIS398 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 501 |
| Chain | Residue |
| B | GLU262 |
| B | ASP393 |
| B | HIS398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 304 |
| Details | Region: {"description":"ROQ","evidences":[{"source":"PubMed","id":"25504471","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26489670","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 138 |
| Details | Region: {"description":"HEPN-C","evidences":[{"source":"PubMed","id":"26489670","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
