4QHU
Crystal Structure of IL-17A/Fab6785 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (L, A) | Fab6785 light chain | polymer | 214 | 22767.1 | 2 | Homo sapiens (human) | ||
| 2 | B, D (H, B) | Fab6785 heavy chain | polymer | 224 | 23868.8 | 2 | Homo sapiens (human) | ||
| 3 | E, F (C, D) | Interleukin-17A | polymer | 132 | 15202.1 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8 |
| 4 | G, H, K, L, M (L, H, A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | I (L) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J, N, O, P, Q (H, B, C, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | R, S, T, U, V... (L, H, A, B, C...) | water | water | 18.0 | 1149 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 131 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Gln 70 | Lys 93 | engineered mutation |
| Gln 132 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 123676.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 976.2 | |
| All* | Total formula weight | 124652.3 |
