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4QHU

Crystal Structure of IL-17A/Fab6785 complex

Functional Information from GO Data
ChainGOidnamespacecontents
C0002225biological_processpositive regulation of antimicrobial peptide production
C0002250biological_processadaptive immune response
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007219biological_processNotch signaling pathway
C0007267biological_processcell-cell signaling
C0008219biological_processcell death
C0009611biological_processresponse to wounding
C0009897cellular_componentexternal side of plasma membrane
C0010467biological_processgene expression
C0030216biological_processkeratinocyte differentiation
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032735biological_processpositive regulation of interleukin-12 production
C0032739biological_processpositive regulation of interleukin-16 production
C0032747biological_processpositive regulation of interleukin-23 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0038173biological_processinterleukin-17A-mediated signaling pathway
C0042803molecular_functionprotein homodimerization activity
C0043616biological_processkeratinocyte proliferation
C0045087biological_processinnate immune response
C0045672biological_processpositive regulation of osteoclast differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046982molecular_functionprotein heterodimerization activity
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0050832biological_processdefense response to fungus
C0060729biological_processintestinal epithelial structure maintenance
C0071347biological_processcellular response to interleukin-1
C0072537biological_processfibroblast activation
C0097400biological_processinterleukin-17-mediated signaling pathway
C0097530biological_processgranulocyte migration
C0106015biological_processnegative regulation of inflammatory response to wounding
C1900017biological_processpositive regulation of cytokine production involved in inflammatory response
C1903348biological_processpositive regulation of bicellular tight junction assembly
C2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
D0002225biological_processpositive regulation of antimicrobial peptide production
D0002250biological_processadaptive immune response
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007219biological_processNotch signaling pathway
D0007267biological_processcell-cell signaling
D0008219biological_processcell death
D0009611biological_processresponse to wounding
D0009897cellular_componentexternal side of plasma membrane
D0010467biological_processgene expression
D0030216biological_processkeratinocyte differentiation
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032735biological_processpositive regulation of interleukin-12 production
D0032739biological_processpositive regulation of interleukin-16 production
D0032747biological_processpositive regulation of interleukin-23 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0038173biological_processinterleukin-17A-mediated signaling pathway
D0042803molecular_functionprotein homodimerization activity
D0043616biological_processkeratinocyte proliferation
D0045087biological_processinnate immune response
D0045672biological_processpositive regulation of osteoclast differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046982molecular_functionprotein heterodimerization activity
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0050832biological_processdefense response to fungus
D0060729biological_processintestinal epithelial structure maintenance
D0071347biological_processcellular response to interleukin-1
D0072537biological_processfibroblast activation
D0097400biological_processinterleukin-17-mediated signaling pathway
D0097530biological_processgranulocyte migration
D0106015biological_processnegative regulation of inflammatory response to wounding
D1900017biological_processpositive regulation of cytokine production involved in inflammatory response
D1903348biological_processpositive regulation of bicellular tight junction assembly
D2000340biological_processpositive regulation of chemokine (C-X-C motif) ligand 1 production
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL L 301
ChainResidue
LGLN36
LVAL44
LPRO58
LHOH404
LHOH454
LHOH588

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL L 302
ChainResidue
LTHR17
LARG19
LHOH449

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL L 303
ChainResidue
LARG191
LHOH583

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 H 301
ChainResidue
HPHE27
HTHR28
HTYR32
HHOH420
HHOH591

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL H 302
ChainResidue
HGLN99
HTHR101
HASP103
HHOH419
LTYR48

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 301
ChainResidue
ATYR31
AASN33
AASP49
AHOH492
BLEU100
BTHR101
DARG55
DGLU57
DVAL65

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 302
ChainResidue
AGLN36
ALYS38
APRO58
APHE61
AGLU80
AASP81
AHOH550

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 301
ChainResidue
BPHE27
BTHR28
BTYR32
BHOH433
BHOH516
BHOH619
BHOH622

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 201
ChainResidue
CHIS73
CLEU74
CGLY75
CVAL83
CTYR85

site_idBC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 C 202
ChainResidue
CASN36
CPRO37
CLYS38
CARG39
CTRP67
CHOH326
CHOH339
DHOH350
LTYR31

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 D 201
ChainResidue
DHIS73
DLEU74
DGLY75
DVAL83
DTYR85
DHOH340

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
LTYR193-HIS199
HTYR196-HIS202

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN45
DASN45

219140

PDB entries from 2024-05-01

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