4QE8
FXR with DM175 and NCoA-2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bile acid receptor | polymer | 233 | 27216.3 | 2 | UniProt (Q96RI1) Pfam (PF00104) | Homo sapiens (human) | Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1593.8 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2 |
| 3 | E, J (A, B) | 4-({2-[(4-tert-butylbenzoyl)amino]benzoyl}amino)benzoic acid | non-polymer | 416.5 | 2 | Chemie (31D) | |||
| 4 | F, G, H, I, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 5 | N (B) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B: 244 - 472 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Gly 240 | - | expression tag |
| Ser 241 | - | expression tag |
| His 242 | - | expression tag |
| Met 243 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57620.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1385.6 | |
| All* | Total formula weight | 59005.8 |
