Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0032052 | molecular_function | bile acid binding |
| B | 0038183 | biological_process | bile acid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 31D A 1001 |
| Chain | Residue |
| A | PHE284 |
| A | SER453 |
| A | ARG455 |
| A | THR288 |
| A | MET290 |
| A | MET328 |
| A | ARG331 |
| A | SER332 |
| A | ILE357 |
| A | MET365 |
| A | MET450 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1002 |
| Chain | Residue |
| A | HOH1106 |
| A | HOH1147 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | LEU305 |
| A | GLY307 |
| A | GLN309 |
| A | THR310 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | ASN444 |
| A | HOH1108 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | GLN249 |
| A | ASP413 |
| A | GLN416 |
| A | LYS417 |
| A | HOH1134 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 31D B 1001 |
| Chain | Residue |
| B | PHE284 |
| B | MET290 |
| B | ALA291 |
| B | HIS294 |
| B | MET328 |
| B | ARG331 |
| B | ILE357 |
| B | MET450 |
| B | SER453 |
| B | TRP469 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 1002 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1003 |
| Chain | Residue |
| B | LYS376 |
| B | GLN423 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1004 |
| Chain | Residue |
| B | THR438 |
| B | ARG441 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MRD B 1005 |
| Chain | Residue |
| A | GLU425 |
| B | PRO393 |
| B | ASP394 |
| site_id | BC2 |
| Number of Residues | 47 |
| Details | BINDING SITE FOR CHAIN B OF BILE ACID RECEPTOR |
| Chain | Residue |
| A | ILE421 |
| A | PRO424 |
| A | GLU425 |
| A | GLN428 |
| A | PHE430 |
| A | ALA431 |
| A | LEU434 |
| B | MET243 |
| B | 31D1001 |
| B | EDO1002 |
| B | EDO1003 |
| B | EDO1004 |
| B | MRD1005 |
| B | HOH1101 |
| B | HOH1103 |
| B | HOH1105 |
| B | HOH1106 |
| B | HOH1108 |
| B | HOH1110 |
| B | HOH1111 |
| B | HOH1112 |
| B | HOH1113 |
| B | HOH1114 |
| B | HOH1117 |
| B | HOH1120 |
| B | HOH1121 |
| B | HOH1124 |
| B | HOH1125 |
| B | HOH1129 |
| B | HOH1133 |
| B | HOH1137 |
| B | HOH1138 |
| B | HOH1139 |
| B | HOH1140 |
| B | HOH1143 |
| B | HOH1145 |
| B | HOH1150 |
| B | HOH1153 |
| B | HOH1154 |
| C | LYS740 |
| C | TYR747 |
| D | ASN742 |
| D | ARG746 |
| D | LEU748 |
| D | LEU749 |
| D | LYS751 |
| D | ASP752 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 3"} |
