4PE5
Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Glutamate receptor ionotropic, NMDA 1 | polymer | 825 | 92680.9 | 2 | UniProt (P35439) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
2 | B, D | Glutamate receptor ionotropic, NMDA 2B | polymer | 820 | 92163.4 | 2 | UniProt (Q00960) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B |
3 | E, I, J | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
4 | F | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
5 | G | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G76865YT) | |||
6 | H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
7 | A, B, C | TUNGSTEN ION | non-polymer | 183.8 | 84 | Chemie (W) | |||
8 | A, C | GLYCINE | non-polymer | 75.1 | 2 | Chemie (GLY) | |||
9 | C, D, B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
10 | B, C | 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol | non-polymer | 325.4 | 2 | Chemie (QEL) | |||
11 | D, B | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) |
Sequence modifications
A, C: 23 - 847 (UniProt: P35439)
B, D: 27 - 852 (UniProt: Q00960)
PDB | External Database | Details |
---|---|---|
Gln 61 | Asn 61 | engineered mutation |
Asp 239 | Asn 239 | engineered mutation |
Gln 350 | Asn 350 | engineered mutation |
Gln 471 | Asn 471 | engineered mutation |
Gln 491 | Asn 491 | engineered mutation |
Cys 561 | Thr 561 | engineered mutation |
Gln 594 | Glu 594 | engineered mutation |
Ser 595 | Glu 595 | engineered mutation |
Ser 597 | Glu 597 | engineered mutation |
Thr 598 | Glu 598 | engineered mutation |
Gln 771 | Asn 771 | engineered mutation |
Cys 810 | Phe 810 | engineered mutation |
Asn 844 | Arg 844 | engineered mutation |
Gly 845 | Arg 845 | engineered mutation |
Ala 846 | Lys 846 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Cys 214 | Ser 214 | engineered mutation |
Asp 348 | Asn 348 | engineered mutation |
- | Cys 395 | deletion |
- | Pro 396 | deletion |
- | Glu 397 | deletion |
- | Glu 399 | deletion |
- | Glu 400 | deletion |
- | Glu 402 | deletion |
Cys 557 | Asp 557 | engineered mutation |
Ser 588 | Cys 588 | engineered mutation |
Cys 815 | Ile 815 | engineered mutation |
Ser 838 | Cys 838 | engineered mutation |
Ser 849 | Cys 849 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 369688.6 | |
Branched | Number of molecules | 6 |
Total formula weight | 4816.4 | |
Non-Polymers* | Number of molecules | 98 |
Total formula weight | 18307.5 | |
All* | Total formula weight | 392812.5 |