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4PE5

Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001661biological_processconditioned taste aversion
A0001666biological_processresponse to hypoxia
A0001964biological_processstartle response
A0001967biological_processsuckling behavior
A0001975biological_processresponse to amphetamine
A0004970molecular_functionglutamate-gated receptor activity
A0004972molecular_functionNMDA glutamate receptor activity
A0005102molecular_functionsignaling receptor binding
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006366biological_processtranscription by RNA polymerase II
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0007268biological_processchemical synaptic transmission
A0007611biological_processlearning or memory
A0007612biological_processlearning
A0007613biological_processmemory
A0007616biological_processlong-term memory
A0008021cellular_componentsynaptic vesicle
A0008306biological_processassociative learning
A0008344biological_processadult locomotory behavior
A0008355biological_processolfactory learning
A0008542biological_processvisual learning
A0009986cellular_componentcell surface
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0010646biological_processregulation of cell communication
A0014069cellular_componentpostsynaptic density
A0014070biological_processresponse to organic cyclic compound
A0014075biological_processresponse to amine
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0016594molecular_functionglycine binding
A0016595molecular_functionglutamate binding
A0017146cellular_componentNMDA selective glutamate receptor complex
A0018964biological_processpropylene metabolic process
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0019899molecular_functionenzyme binding
A0019902molecular_functionphosphatase binding
A0021586biological_processpons maturation
A0021987biological_processcerebral cortex development
A0022843molecular_functionvoltage-gated monoatomic cation channel activity
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0022890molecular_functioninorganic cation transmembrane transporter activity
A0030425cellular_componentdendrite
A0030672cellular_componentsynaptic vesicle membrane
A0032590cellular_componentdendrite membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035176biological_processsocial behavior
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0035254molecular_functionglutamate receptor binding
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043083cellular_componentsynaptic cleft
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0043226cellular_componentorganelle
A0043278biological_processresponse to morphine
A0043523biological_processregulation of neuron apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043576biological_processregulation of respiratory gaseous exchange
A0044307cellular_componentdendritic branch
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045471biological_processresponse to ethanol
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048167biological_processregulation of synaptic plasticity
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048511biological_processrhythmic process
A0048787cellular_componentpresynaptic active zone membrane
A0048814biological_processregulation of dendrite morphogenesis
A0050770biological_processregulation of axonogenesis
A0050905biological_processneuromuscular process
A0051290biological_processprotein heterotetramerization
A0051592biological_processresponse to calcium ion
A0051963biological_processregulation of synapse assembly
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0055074biological_processcalcium ion homeostasis
A0060076cellular_componentexcitatory synapse
A0060079biological_processexcitatory postsynaptic potential
A0060134biological_processprepulse inhibition
A0060179biological_processmale mating behavior
A0060992biological_processresponse to fungicide
A0065003biological_processprotein-containing complex assembly
A0070050biological_processneuron cellular homeostasis
A0071287biological_processcellular response to manganese ion
A0097060cellular_componentsynaptic membrane
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098655biological_processmonoatomic cation transmembrane transport
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1900149biological_processpositive regulation of Schwann cell migration
A1902952biological_processpositive regulation of dendritic spine maintenance
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1903539biological_processprotein localization to postsynaptic membrane
A1904062biological_processregulation of monoatomic cation transmembrane transport
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904646biological_processcellular response to amyloid-beta
A1905429biological_processresponse to glycine
A1905430biological_processcellular response to glycine
A2000463biological_processpositive regulation of excitatory postsynaptic potential
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0001540molecular_functionamyloid-beta binding
C0001661biological_processconditioned taste aversion
C0001666biological_processresponse to hypoxia
C0001964biological_processstartle response
C0001967biological_processsuckling behavior
C0001975biological_processresponse to amphetamine
C0004970molecular_functionglutamate-gated receptor activity
C0004972molecular_functionNMDA glutamate receptor activity
C0005102molecular_functionsignaling receptor binding
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006366biological_processtranscription by RNA polymerase II
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0007268biological_processchemical synaptic transmission
C0007611biological_processlearning or memory
C0007612biological_processlearning
C0007613biological_processmemory
C0007616biological_processlong-term memory
C0008021cellular_componentsynaptic vesicle
C0008306biological_processassociative learning
C0008344biological_processadult locomotory behavior
C0008355biological_processolfactory learning
C0008542biological_processvisual learning
C0009986cellular_componentcell surface
C0010524biological_processpositive regulation of calcium ion transport into cytosol
C0010646biological_processregulation of cell communication
C0014069cellular_componentpostsynaptic density
C0014070biological_processresponse to organic cyclic compound
C0014075biological_processresponse to amine
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0016594molecular_functionglycine binding
C0016595molecular_functionglutamate binding
C0017146cellular_componentNMDA selective glutamate receptor complex
C0018964biological_processpropylene metabolic process
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0019899molecular_functionenzyme binding
C0019902molecular_functionphosphatase binding
C0021586biological_processpons maturation
C0021987biological_processcerebral cortex development
C0022843molecular_functionvoltage-gated monoatomic cation channel activity
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0022890molecular_functioninorganic cation transmembrane transporter activity
C0030425cellular_componentdendrite
C0030672cellular_componentsynaptic vesicle membrane
C0032590cellular_componentdendrite membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035176biological_processsocial behavior
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0035254molecular_functionglutamate receptor binding
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043083cellular_componentsynaptic cleft
C0043195cellular_componentterminal bouton
C0043197cellular_componentdendritic spine
C0043226cellular_componentorganelle
C0043278biological_processresponse to morphine
C0043523biological_processregulation of neuron apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0043576biological_processregulation of respiratory gaseous exchange
C0044307cellular_componentdendritic branch
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045471biological_processresponse to ethanol
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048167biological_processregulation of synaptic plasticity
C0048168biological_processregulation of neuronal synaptic plasticity
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048511biological_processrhythmic process
C0048787cellular_componentpresynaptic active zone membrane
C0048814biological_processregulation of dendrite morphogenesis
C0050770biological_processregulation of axonogenesis
C0050905biological_processneuromuscular process
C0051290biological_processprotein heterotetramerization
C0051592biological_processresponse to calcium ion
C0051963biological_processregulation of synapse assembly
C0051968biological_processpositive regulation of synaptic transmission, glutamatergic
C0055074biological_processcalcium ion homeostasis
C0060076cellular_componentexcitatory synapse
C0060079biological_processexcitatory postsynaptic potential
C0060134biological_processprepulse inhibition
C0060179biological_processmale mating behavior
C0060992biological_processresponse to fungicide
C0065003biological_processprotein-containing complex assembly
C0070050biological_processneuron cellular homeostasis
C0071287biological_processcellular response to manganese ion
C0097060cellular_componentsynaptic membrane
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098655biological_processmonoatomic cation transmembrane transport
C0098686cellular_componenthippocampal mossy fiber to CA3 synapse
C0098688cellular_componentparallel fiber to Purkinje cell synapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1900149biological_processpositive regulation of Schwann cell migration
C1902952biological_processpositive regulation of dendritic spine maintenance
C1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
C1903539biological_processprotein localization to postsynaptic membrane
C1904062biological_processregulation of monoatomic cation transmembrane transport
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1904646biological_processcellular response to amyloid-beta
C1905429biological_processresponse to glycine
C1905430biological_processcellular response to glycine
C2000463biological_processpositive regulation of excitatory postsynaptic potential
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1400
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:24876489
ChainResidueDetails
BARG27-PHE563
BPHE653-TYR823
DARG27-PHE563
DPHE653-TYR823
CILE631-TYR647
CMET813-ILE833

site_idSWS_FT_FI2
Number of Residues104
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:24876489
ChainResidueDetails
BVAL564-PRO582
BPHE637-ALA652
BMET824-TYR843
DVAL564-PRO582
DPHE637-ALA652
DMET824-TYR843

site_idSWS_FT_FI3
Number of Residues64
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24876489
ChainResidueDetails
BVAL583-LEU609
BILE630-ALA636
DVAL583-LEU609
DILE630-ALA636

site_idSWS_FT_FI4
Number of Residues38
DetailsINTRAMEM: Discontinuously helical => ECO:0000305|PubMed:24876489
ChainResidueDetails
BTRP610-LYS629
DTRP610-LYS629

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
ChainResidueDetails
BHIS127
BGLU284
DHIS127
DGLU284

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
ChainResidueDetails
BSER520
BPHE525
BTYR738
DSER520
DPHE525
DTYR738

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:4PE5
ChainResidueDetails
BARG696
DARG696
CGLN61
CASP239

site_idSWS_FT_FI8
Number of Residues2
DetailsSITE: Functional determinant of NMDA receptors => ECO:0000250
ChainResidueDetails
BGLN621
DGLN621
CASN203
CASN368

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5
ChainResidueDetails
BASN74
DASN74

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ
ChainResidueDetails
BASN341
DASN341

site_idSWS_FT_FI11
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASP348
BPRO450
BMET497
BSER548
DASP348
DPRO450
DMET497
DSER548

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
ChainResidueDetails
BASN694
DASN694

site_idSWS_FT_FI13
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN471
AGLN491
AASN674
CGLN471
CGLN491
CASN674

221371

PDB entries from 2024-06-19

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