4P7I
Crystal structure of the Merlin FERM/DCAF1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Merlin | polymer | 317 | 37245.1 | 2 | UniProt (P46662) Pfam (PF09379) Pfam (PF00373) Pfam (PF09380) | Mus musculus (Mouse) | Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomin |
| 2 | C, D (C, D) | Protein VPRBP | polymer | 67 | 7180.0 | 2 | UniProt (Q9Y4B6) | Homo sapiens (Human) | DDB1- and CUL4-associated factor 1,HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 3 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 313 (UniProt: P46662)
C, D: 1447 - 1507 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1441 | - | expression tag |
| Pro 1442 | - | expression tag |
| Gly 1443 | - | expression tag |
| Ser 1444 | - | expression tag |
| Glu 1445 | - | expression tag |
| Phe 1446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88850.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 88942.3 |
