4P7I

Crystal structure of the Merlin FERM/DCAF1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Merlin	polymer	317	37245.1	2	UniProt (P46662) Pfam (PF09379) Pfam (PF00373) Pfam (PF09380) In PDB	Mus musculus (Mouse)	Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomin
2	C, D	Protein VPRBP	polymer	67	7180.0	2	UniProt (Q9Y4B6) In PDB	Homo sapiens (Human)	DDB1- and CUL4-associated factor 1,HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	31	Chemie (HOH)

Sequence modifications

A, B: 1 - 313 (UniProt: P46662)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

C, D: 1447 - 1507 (UniProt: Q9Y4B6)

PDB	External Database	Details
Gly 1441	-	expression tag
Pro 1442	-	expression tag
Gly 1443	-	expression tag
Ser 1444	-	expression tag
Glu 1445	-	expression tag
Phe 1446	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88850.2
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	88942.3

*Water molecules are not included.