4P4H

Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Probable ATP-dependent RNA helicase DDX58	polymer	205	24014.5	8	UniProt (O95786) Pfam (PF16739) In PDB	Homo sapiens (Human)	DEAD box protein 58,RIG-I-like receptor 1,RLR-1,Retinoic acid-inducible gene 1 protein,RIG-1,Retinoic acid-inducible gene I protein,RIG-I
2	I, J, K, L, N...	Mitochondrial antiviral-signaling protein	polymer	108	12292.0	8	UniProt (Q7Z434) Pfam (PF16739) In PDB	Homo sapiens (Human)	MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA
3	S, T, U, W, X	Ubiquitin-60S ribosomal protein L40	polymer	79	8788.0	5	UniProt (P62987) Pfam (PF00240) In PDB	Homo sapiens (Human)	CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 201 (UniProt: O95786)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Ala 52	Glu 52	engineered mutation

I, J, K, L, N, O, P, M: 1 - 99 (UniProt: Q7Z434)

PDB	External Database	Details
Gly -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Thr -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Thr -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Lys 23	Asp 23	engineered mutation
Lys 26	Glu 26	engineered mutation
Lys 80	Glu 80	engineered mutation

S, T, U, W, X: 1 - 76 (UniProt: P62987)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	21
	Total formula weight	334392.8
All*	Total formula weight	334392.8

*Water molecules are not included.