4P1R
Crystal Structure of PDE10A with Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 338 | 38889.6 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | B, A | SULFATE ION | non-polymer | 96.1 | 26 | Chemie (SO4) | |||
| 4 | B, A | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | B, A | N-[4-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]-5-methylpyridin-2-amine | non-polymer | 331.4 | 2 | Chemie (2KR) | |||
| 6 | water | water | 18.0 | 691 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77779.2 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 4158.8 | |
| All* | Total formula weight | 81937.9 |
