Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | HIS519 |
| A | HIS553 |
| A | ASP554 |
| A | ASP664 |
| A | ZN1002 |
| A | HOH1261 |
| A | HOH1352 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | HOH1202 |
| A | HOH1225 |
| A | HOH1227 |
| A | HOH1261 |
| A | HOH1262 |
| A | ASP554 |
| A | ZN1001 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | PHE472 |
| A | GLU473 |
| A | ASN474 |
| A | ARG510 |
| A | ARG558 |
| A | HOH1101 |
| A | HOH1107 |
| A | HOH1125 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1004 |
| Chain | Residue |
| A | LYS497 |
| A | GLY597 |
| A | HIS598 |
| A | ASN599 |
| A | HOH1215 |
| A | HOH1254 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1005 |
| Chain | Residue |
| A | VAL512 |
| A | PRO513 |
| A | ARG558 |
| A | GLY559 |
| A | GLU685 |
| A | ALA688 |
| A | HOH1144 |
| A | HOH1380 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1006 |
| Chain | Residue |
| A | LEU537 |
| A | LEU646 |
| A | ASN647 |
| A | ARG652 |
| B | LEU537 |
| B | LEU646 |
| B | ASN647 |
| B | ARG652 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1007 |
| Chain | Residue |
| A | ARG510 |
| A | ARG511 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1008 |
| Chain | Residue |
| A | PHE629 |
| A | PHE719 |
| A | VAL723 |
| A | GOL1018 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1009 |
| Chain | Residue |
| A | GLN532 |
| A | ASN533 |
| A | HOH1382 |
| B | TYR639 |
| B | SO4814 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1010 |
| Chain | Residue |
| A | SER577 |
| A | THR578 |
| A | GLN583 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1011 |
| Chain | Residue |
| A | ASN508 |
| A | GLN588 |
| A | SER591 |
| A | ILE592 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1012 |
| Chain | Residue |
| A | ASN599 |
| A | PHE601 |
| A | SER602 |
| A | LEU604 |
| A | TYR609 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1013 |
| Chain | Residue |
| A | THR539 |
| A | ASP540 |
| A | HOH1396 |
| B | ASN645 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 1014 |
| Chain | Residue |
| A | SER650 |
| A | HIS651 |
| A | ARG654 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1015 |
| Chain | Residue |
| A | ARG457 |
| A | GLU461 |
| A | HIS466 |
| A | PHE467 |
| A | ASP468 |
| A | LEU671 |
| A | HOH1111 |
| A | HOH1121 |
| A | HOH1146 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 1016 |
| Chain | Residue |
| A | PRO673 |
| A | LYS676 |
| A | LEU677 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1017 |
| Chain | Residue |
| A | LYS694 |
| A | GLY697 |
| A | ILE698 |
| A | GLN699 |
| A | HOH1106 |
| A | HOH1133 |
| A | HOH1301 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1018 |
| Chain | Residue |
| A | HOH1437 |
| A | ILE701 |
| A | PRO702 |
| A | MET703 |
| A | SO41008 |
| A | 2KR1020 |
| A | HOH1224 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1019 |
| Chain | Residue |
| A | ARG486 |
| A | GLN532 |
| A | HIS535 |
| A | HOH1185 |
| B | SO4814 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue 2KR A 1020 |
| Chain | Residue |
| A | ILE682 |
| A | TYR683 |
| A | PRO702 |
| A | MET703 |
| A | LYS708 |
| A | GLU711 |
| A | GLN716 |
| A | PHE719 |
| A | GOL1018 |
| A | HOH1308 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS519 |
| B | HIS553 |
| B | ASP554 |
| B | ASP664 |
| B | HOH1033 |
| B | HOH1091 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 802 |
| Chain | Residue |
| B | ASP554 |
| B | HOH977 |
| B | HOH982 |
| B | HOH1033 |
| B | HOH1058 |
| B | HOH1090 |
| site_id | AE5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| B | PHE472 |
| B | GLU473 |
| B | ASN474 |
| B | ARG510 |
| B | ARG558 |
| B | HIS570 |
| B | HOH902 |
| B | HOH923 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| B | ARG510 |
| B | ARG511 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 805 |
| Chain | Residue |
| B | PRO673 |
| B | LYS694 |
| B | GLY697 |
| B | ILE698 |
| B | GLN699 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 806 |
| Chain | Residue |
| A | THR641 |
| A | GLY642 |
| A | SER643 |
| B | ARG486 |
| B | SER487 |
| B | CYS488 |
| B | GLY489 |
| B | HIS535 |
| B | ARG543 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 807 |
| Chain | Residue |
| B | LYS497 |
| B | GLY597 |
| B | HIS598 |
| B | ASN599 |
| B | HOH993 |
| B | HOH994 |
| B | HOH1020 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 808 |
| Chain | Residue |
| A | ASN645 |
| B | THR539 |
| B | ASP540 |
| B | HOH1236 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 809 |
| Chain | Residue |
| B | ASN508 |
| B | GLN588 |
| B | ILE592 |
| B | HOH1003 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 810 |
| Chain | Residue |
| B | VAL512 |
| B | PRO513 |
| B | ARG558 |
| B | GLY559 |
| B | GLU685 |
| B | ALA688 |
| B | HOH925 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 811 |
| Chain | Residue |
| B | ASN680 |
| B | TRP687 |
| B | VAL712 |
| B | HOH1114 |
| B | HOH1204 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 812 |
| Chain | Residue |
| B | ASN599 |
| B | PHE601 |
| B | SER602 |
| B | LEU604 |
| B | TYR609 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 813 |
| Chain | Residue |
| B | GLU739 |
| B | LEU742 |
| B | ARG746 |
| B | HOH1129 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 814 |
| Chain | Residue |
| A | SO41009 |
| A | SO41019 |
| B | TYR639 |
| site_id | AF8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 815 |
| Chain | Residue |
| B | SER605 |
| B | SER605 |
| B | SER605 |
| B | SER606 |
| B | SER606 |
| B | SER606 |
| B | HOH906 |
| B | HOH906 |
| B | HOH906 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 816 |
| Chain | Residue |
| B | LEU625 |
| B | PHE719 |
| B | GOL819 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 817 |
| Chain | Residue |
| B | ARG457 |
| B | GLU461 |
| B | PHE467 |
| B | ASP468 |
| B | HOH905 |
| B | HOH911 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 818 |
| Chain | Residue |
| A | PRO736 |
| A | HOH1191 |
| B | ASN533 |
| B | PRO737 |
| B | HOH1153 |
| B | HOH1156 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 819 |
| Chain | Residue |
| B | PRO702 |
| B | MET703 |
| B | SO4816 |
| B | 2KR820 |
| B | HOH1008 |
| B | HOH1155 |
| site_id | AG4 |
| Number of Residues | 12 |
| Details | binding site for residue 2KR B 820 |
| Chain | Residue |
| B | SER667 |
| B | TYR683 |
| B | PHE686 |
| B | PRO702 |
| B | MET703 |
| B | LYS708 |
| B | GLU711 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
| B | GOL819 |
| B | HOH1044 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 317 |
| Details | Domain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
