4OT1
Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by the Neutralizing Human Antibody SM5-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope glycoprotein B | polymer | 129 | 14427.1 | 1 | UniProt (P13201) Pfam (PF17416) Pfam (PF17417) | Human Cytomegalovirus (HHV-5) | gB, Glycoprotein GP55 |
| 2 | B (H) | SM5-1 Fab Heavy Chain | polymer | 234 | 24878.0 | 1 | Homo sapiens | ||
| 3 | C (L) | SM5-1 Fab Light Chain | polymer | 215 | 22569.1 | 1 | Homo sapiens | ||
| 4 | D, E, G (A, H, L) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | F (L) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | H, I, J (A, H, L) | water | water | 18.0 | 248 | Chemie (HOH) |
Sequence modifications
A: 114 - 133 (UniProt: P13201)
A: 344 - 438 (UniProt: P13201)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | expression tag |
| Pro 105 | - | expression tag |
| Leu 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Pro 109 | - | expression tag |
| Glu 110 | - | expression tag |
| Phe 111 | - | expression tag |
| Thr 112 | - | expression tag |
| Ser 113 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 201 | - | linker |
| Gly 202 | - | linker |
| Ser 203 | - | linker |
| Gly 204 | - | linker |
| Ala 397 | Ile 397 | engineered mutation |
| Ala 398 | Asn 398 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 61874.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 424.5 | |
| All* | Total formula weight | 62298.7 |
