4OLF
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proline--tRNA ligase | polymer | 506 | 58986.5 | 1 | UniProt (Q8I5R7) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) In PDB | Plasmodium falciparum | Prolyl-tRNA synthetase, ProRS |
| 2 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | A | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 1 | Chemie (HFG) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 249 - 746 (UniProt: Q8I5R7)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | expression tag |
| Ala 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 58986.5 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2446.9 | |
| All* | Total formula weight | 61433.4 |
