4OLF
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ANP A 801 |
| Chain | Residue |
| A | ARG390 |
| A | ALA477 |
| A | THR512 |
| A | ARG514 |
| A | HFG802 |
| A | NA818 |
| A | HOH904 |
| A | HOH905 |
| A | GLU392 |
| A | ILE400 |
| A | ARG401 |
| A | THR402 |
| A | PHE405 |
| A | TRP407 |
| A | GLN475 |
| A | ALA476 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HFG A 802 |
| Chain | Residue |
| A | PHE335 |
| A | GLU338 |
| A | VAL339 |
| A | PRO358 |
| A | THR359 |
| A | GLU361 |
| A | ARG390 |
| A | TRP407 |
| A | PHE454 |
| A | THR478 |
| A | HIS480 |
| A | SER508 |
| A | TRP509 |
| A | GLY510 |
| A | ANP801 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 803 |
| Chain | Residue |
| A | ASN261 |
| A | PHE262 |
| A | SER263 |
| A | HOH907 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 804 |
| Chain | Residue |
| A | TYR278 |
| A | SER282 |
| A | GLY283 |
| A | TYR285 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 805 |
| Chain | Residue |
| A | GLU312 |
| A | TYR538 |
| A | ARG593 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 806 |
| Chain | Residue |
| A | GLY334 |
| A | PHE335 |
| A | SER336 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 807 |
| Chain | Residue |
| A | ARG376 |
| A | ARG578 |
| A | ALA579 |
| A | SER580 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 808 |
| Chain | Residue |
| A | GLU274 |
| A | HIS589 |
| A | TRP590 |
| A | ARG593 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 809 |
| Chain | Residue |
| A | LYS258 |
| A | GLU469 |
| A | THR522 |
| A | HIS523 |
| A | GLY524 |
| A | LYS651 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 810 |
| Chain | Residue |
| A | SER282 |
| A | ARG403 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 811 |
| Chain | Residue |
| A | TYR293 |
| A | GLU296 |
| A | CYS297 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 812 |
| Chain | Residue |
| A | TYR293 |
| A | LYS537 |
| A | ASN572 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 813 |
| Chain | Residue |
| A | TYR292 |
| A | GLU296 |
| A | GLN299 |
| A | GLN299 |
| A | ASN303 |
| A | ASN313 |
| A | TRP385 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 814 |
| Chain | Residue |
| A | ASN303 |
| A | LYS307 |
| A | VAL311 |
| A | GLU312 |
| A | ASN313 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 815 |
| Chain | Residue |
| A | GLU417 |
| A | TYR481 |
| A | GLY483 |
| A | THR484 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 816 |
| Chain | Residue |
| A | ASN618 |
| A | GLU620 |
| A | ASN643 |
| A | LYS647 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 817 |
| Chain | Residue |
| A | ASN623 |
| A | ARG695 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 818 |
| Chain | Residue |
| A | GLN475 |
| A | ARG514 |
| A | SER745 |
| A | TYR746 |
| A | ANP801 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 819 |
| Chain | Residue |
| A | GLU277 |
| A | ARG288 |
| A | LYS370 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25817387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27798837","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2014","submissionDatabase":"PDB data bank","title":"Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP.","authors":["Dranow D.M.","Edwards T.E.","Lorimer D."]}},{"source":"PDB","id":"4OLF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Q15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YDQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2019","submissionDatabase":"PDB data bank","title":"Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with NCP-26 and L-Proline.","authors":["Johansson C.","Wang J.","Tye M.","Payne N.C.","Mazitschek R.","Thompson A.","Arrowsmith C.H.","Bountra C.","Edwards A.","Oppermann U.C.T."]}},{"source":"PDB","id":"6T7K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
