4OLF

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004827	molecular_function	proline-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006433	biological_process	prolyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP A 801

Chain	Residue
A	ARG390
A	ALA477
A	THR512
A	ARG514
A	HFG802
A	NA818
A	HOH904
A	HOH905
A	GLU392
A	ILE400
A	ARG401
A	THR402
A	PHE405
A	TRP407
A	GLN475
A	ALA476

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HFG A 802

Chain	Residue
A	PHE335
A	GLU338
A	VAL339
A	PRO358
A	THR359
A	GLU361
A	ARG390
A	TRP407
A	PHE454
A	THR478
A	HIS480
A	SER508
A	TRP509
A	GLY510
A	ANP801

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 803

Chain	Residue
A	ASN261
A	PHE262
A	SER263
A	HOH907

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 804

Chain	Residue
A	TYR278
A	SER282
A	GLY283
A	TYR285

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 805

Chain	Residue
A	GLU312
A	TYR538
A	ARG593

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 806

Chain	Residue
A	GLY334
A	PHE335
A	SER336

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 807

Chain	Residue
A	ARG376
A	ARG578
A	ALA579
A	SER580

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 808

Chain	Residue
A	GLU274
A	HIS589
A	TRP590
A	ARG593

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 809

Chain	Residue
A	LYS258
A	GLU469
A	THR522
A	HIS523
A	GLY524
A	LYS651

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 810

Chain	Residue
A	SER282
A	ARG403

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 811

Chain	Residue
A	TYR293
A	GLU296
A	CYS297

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 812

Chain	Residue
A	TYR293
A	LYS537
A	ASN572

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 813

Chain	Residue
A	TYR292
A	GLU296
A	GLN299
A	GLN299
A	ASN303
A	ASN313
A	TRP385

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 814

Chain	Residue
A	ASN303
A	LYS307
A	VAL311
A	GLU312
A	ASN313

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 815

Chain	Residue
A	GLU417
A	TYR481
A	GLY483
A	THR484

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 816

Chain	Residue
A	ASN618
A	GLU620
A	ASN643
A	LYS647

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 817

Chain	Residue
A	ASN623
A	ARG695

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 818

Chain	Residue
A	GLN475
A	ARG514
A	SER745
A	TYR746
A	ANP801

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 819

Chain	Residue
A	GLU277
A	ARG288
A	LYS370

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|Ref.7, ECO:0007744|PDB:6T7K

Chain	Residue	Details
A	ARG390
A	HIS480

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25817387, ECO:0000269|PubMed:27798837, ECO:0000269|Ref.4, ECO:0007744|PDB:4OLF, ECO:0007744|PDB:4Q15, ECO:0007744|PDB:4YDQ

Chain	Residue	Details
A	THR512
A	ARG401
A	GLN475

---