4O5I

Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Hemagglutinin HA1 chain	polymer	323	35934.5	6	UniProt (R9U684) Pfam (PF00509) In PDB	Influenza A virus
2	B, D, F, H, J...	Hemagglutinin HA2 chain	polymer	176	20153.4	6	UniProt (R9U684) Pfam (PF00509) In PDB	Influenza A virus
3	M, O, Q, S, U...	Fab F045-092 heavy chain	polymer	240	25719.7	6	UniProt (S6C4S0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (human)
4	N, P, R, T, V...	Fab F045-092 light chain	polymer	216	22626.9	6	UniProt (P0CG05) In PDB	Homo sapiens (human)
5	0, 3, 5, 6, i...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	13	In PDB GlyTouCan (G15407YE)
6	a, 1, c, 2, d...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
7	b, h, k, n	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	4	In PDB GlyTouCan (G22768VO)
8	e, g, m	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
9	B, C, D, E, F...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)

Sequence modifications

A, C, E, G, I, K: 11 - 329 (UniProt: R9U684)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag

M, O, Q, S, U, W: 1 - 131 (PDB: 4O5I)
M, O, Q, S, U, W: 132 - 216 (UniProt: S6C4S0)

PDB	External Database	Details
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag

N, P, R, T, V, X: 1 - 112 (PDB: 4O5I)
N, P, R, T, V, X: 113 - 212 (UniProt: P0CG05)

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	626606.9
Branched	Number of molecules	35
	Total formula weight	19880.4
Non-Polymers*	Number of molecules	12
	Total formula weight	2654.5
All*	Total formula weight	649141.8

*Water molecules are not included.