4O5I
Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Hemagglutinin HA1 chain | polymer | 323 | 35934.5 | 6 | UniProt (R9U684) Pfam (PF00509) | Influenza A virus | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Hemagglutinin HA2 chain | polymer | 176 | 20153.4 | 6 | UniProt (R9U684) Pfam (PF00509) | Influenza A virus | |
| 3 | M, O, Q, S, U... (M, O, Q, S, U...) | Fab F045-092 heavy chain | polymer | 240 | 25719.7 | 6 | UniProt (S6C4S0) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (human) | |
| 4 | N, P, R, T, V... (N, P, R, T, V...) | Fab F045-092 light chain | polymer | 216 | 22626.9 | 6 | UniProt (P0CG05) Pfam (PF07654) UniProt (by SIFTS) (P0DOY2) | Homo sapiens (human) | |
| 5 | AB, DB, FB, GB, IA... (0, 3, 5, 6, i...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 13 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, BB, CA, CB, DA... (a, 1, c, 2, d...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 15 | In PDB GlyTouCan (G42666HT) | |||
| 7 | BA, HA, KA, NA (b, h, k, n) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 8 | EA, GA, MA (e, g, m) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 9 | HB, IB, JB, KB, LB... (B, C, D, E, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A, C, E, G, I, K: 11 - 329 (UniProt: R9U684)
M, O, Q, S, U, W: 1 - 131 (PDB: 4O5I)
M, O, Q, S, U, W: 132 - 216 (UniProt: S6C4S0)
N, P, R, T, V, X: 1 - 112 (PDB: 4O5I)
N, P, R, T, V, X: 113 - 212 (UniProt: P0CG05)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
M, O, Q, S, U, W: 132 - 216 (UniProt: S6C4S0)
| PDB | External Database | Details |
|---|---|---|
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
N, P, R, T, V, X: 113 - 212 (UniProt: P0CG05)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 626606.9 | |
| Branched | Number of molecules | 35 |
| Total formula weight | 19880.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 649141.8 |
