4O58
Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hemagglutinin HA1 chain | polymer | 323 | 35453.8 | 1 | UniProt (P03435) Pfam (PF00509) | Influenza A virus | |
| 2 | B (B) | Hemagglutinin HA2 chain | polymer | 176 | 20225.4 | 1 | UniProt (P03435) Pfam (PF00509) | Influenza A virus | |
| 3 | C (L) | Fab F045-092 light chain | polymer | 216 | 22626.9 | 1 | UniProt (P0CG05) Pfam (PF07654) UniProt (by SIFTS) (P0DOY2) | Homo sapiens (human) | |
| 4 | D (H) | Fab F045-092 heavy chain | polymer | 240 | 25719.7 | 1 | UniProt (S6C4S0) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (human) | |
| 5 | E, G (C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 7 | H, O (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 8 | I, J, K, L, M... (A, B, L, H) | SULFATE ION | non-polymer | 96.1 | 14 | Chemie (SO4) | |||
| 9 | N, U, V (A, L) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 10 | AA, BA, CA, DA (A, B, L, H) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 11 - 329 (UniProt: P03435)
L: 1 - 112 (PDB: 4O58)
L: 113 - 212 (UniProt: P0CG05)
H: 1 - 131 (PDB: 4O58)
H: 132 - 216 (UniProt: S6C4S0)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
L: 113 - 212 (UniProt: P0CG05)
H: 1 - 131 (PDB: 4O58)
H: 132 - 216 (UniProt: S6C4S0)
| PDB | External Database | Details |
|---|---|---|
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 104025.9 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2105.7 | |
| All* | Total formula weight | 107891.1 |
