4NQA

Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H	Retinoic acid receptor RXR-alpha	polymer	365	41120.4	2	UniProt (P19793) Pfam (PF00105) Pfam (PF00104) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
2	B, I	Liver X nuclear receptor beta	polymer	391	44062.5	2	UniProt (F1D8P7) Pfam (PF00105) Pfam (PF00104) UniProt (by SIFTS) (P55055) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 1, group H, member 2, isoform CRA_c
3	C, D, J, K	Nuclear receptor coactivator 2	polymer	13	1579.9	4	UniProt (Q15596) In PDB	Homo sapiens (human)	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
4	E, L	5'-D(*TP*AP*AP*GP*GP*TP*CP*AP*CP*TP*TP*CP*AP*GP*GP*TP*CP*A)-3'	polymer	18	5515.6	2		synthetic construct
5	F, M	5'-D(*TP*AP*TP*GP*AP*CP*CP*TP*GP*AP*AP*GP*TP*GP*AP*CP*CP*T)-3'	polymer	18	5515.6	2		synthetic construct
6	A, H	(9cis)-retinoic acid	non-polymer		300.4	2	Chemie (9CR)
7	A, B, H, I	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
8	B, I	[3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid	non-polymer		582.1	2	Chemie (965)

Sequence modifications

B, I: 72 - 461 (UniProt: F1D8P7)

PDB	External Database	Details
Met 71	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	198747.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2288.2
All*	Total formula weight	201035.7

*Water molecules are not included.