Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4NQA

Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0004879	molecular_function	nuclear receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006629	biological_process	lipid metabolic process
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0003707	molecular_function	nuclear steroid receptor activity
H	0005634	cellular_component	nucleus
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0043565	molecular_function	sequence-specific DNA binding
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0004879	molecular_function	nuclear receptor activity
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006629	biological_process	lipid metabolic process
I	0008270	molecular_function	zinc ion binding
I	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 9CR A 501

Chain	Residue
A	ILE268
A	GLN275
A	PHE313
A	ARG316
A	ALA327
A	CYS432
A	HIS435

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS152
A	CYS155
A	ARG184
A	CYS135
A	CYS138

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS171
A	CYS177
A	CYS187
A	CYS190

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 965 B 501

Chain	Residue
B	PHE271
B	LEU274
B	ALA275
B	SER278
B	ILE309
B	MET312
B	LEU313
B	THR316
B	ARG319
B	PHE329
B	LEU330
B	PHE340
B	PHE354
B	HIS435
B	TRP457

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS87
B	CYS90
B	CYS104
B	CYS107

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 503

Chain	Residue
B	CYS125
B	CYS131
B	CYS141
B	CYS144

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 9CR H 501

Chain	Residue
H	ALA271
H	GLN275
H	PHE313
H	ARG316
H	LEU326
H	ALA327
H	ILE345
H	CYS432

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 502

Chain	Residue
H	CYS135
H	CYS138
H	CYS152
H	CYS155

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 503

Chain	Residue
H	CYS171
H	CYS177
H	CYS187
H	CYS190

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 965 I 501

Chain	Residue
I	PHE271
I	LEU274
I	ALA275
I	SER278
I	GLU281
I	MET312
I	LEU313
I	THR316
I	ARG319
I	PHE329
I	LEU330
I	PHE340
I	LEU345
I	PHE349
I	ILE350
I	ILE353
I	PHE354
I	HIS435
I	TRP457

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 502

Chain	Residue
I	CYS87
I	CYS90
I	CYS104
I	CYS107

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 503

Chain	Residue
I	CYS125
I	CYS131
I	CYS141
I	CYS144

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CrvCg.Dkasgf.HYnvlsCegCkgFFrR

Chain	Residue	Details
B	CYS87-ARG113
A	CYS135-ARG161

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	154
Details	DNA_BIND: Nuclear receptor => ECO:0000255\|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	HIS84-SER161
I	HIS84-SER161

site_id	SWS_FT_FI2
Number of Residues	88
Details	ZN_FING: NR C4-type => ECO:0000255\|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	CYS87-CYS107
B	CYS125-CYS149
I	CYS87-CYS107
I	CYS125-CYS149

site_id	SWS_FT_FI3
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000269\|PubMed:20159957

Chain	Residue	Details
B	LYS410
H	CYS138
H	CYS152
H	CYS155
H	CYS171
H	CYS177
H	CYS187
H	CYS190
A	CYS138
B	LYS448
I	LYS410
A	CYS171
I	LYS448
A	CYS187
A	CYS190
H	CYS135

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:16107141, ECO:0000269\|PubMed:18800767, ECO:0000269\|PubMed:19167885, ECO:0007744\|PDB:2ACL, ECO:0007744\|PDB:3FAL, ECO:0007744\|PDB:3FC6

Chain	Residue	Details
A	ARG316
A	ALA327
H	ARG316
H	ALA327

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER129
H	SER129

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by EP300 => ECO:0000269\|PubMed:17761950

Chain	Residue	Details
A	LYS145
H	LYS145

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER259
H	SER259

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250\|UniProtKB:P28700

Chain	Residue	Details
A	SER260
H	SER260

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269\|PubMed:16912044

Chain	Residue	Details
A	LYS108
H	LYS108

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)