Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4NQA

Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0004879	molecular_function	nuclear receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006629	biological_process	lipid metabolic process
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0003707	molecular_function	nuclear steroid receptor activity
H	0005634	cellular_component	nucleus
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0043565	molecular_function	sequence-specific DNA binding
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0004879	molecular_function	nuclear receptor activity
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006629	biological_process	lipid metabolic process
I	0008270	molecular_function	zinc ion binding
I	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 9CR A 501

Chain	Residue
A	ILE268
A	GLN275
A	PHE313
A	ARG316
A	ALA327
A	CYS432
A	HIS435

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS152
A	CYS155
A	ARG184
A	CYS135
A	CYS138

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS171
A	CYS177
A	CYS187
A	CYS190

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 965 B 501

Chain	Residue
B	PHE271
B	LEU274
B	ALA275
B	SER278
B	ILE309
B	MET312
B	LEU313
B	THR316
B	ARG319
B	PHE329
B	LEU330
B	PHE340
B	PHE354
B	HIS435
B	TRP457

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS87
B	CYS90
B	CYS104
B	CYS107

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 503

Chain	Residue
B	CYS125
B	CYS131
B	CYS141
B	CYS144

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 9CR H 501

Chain	Residue
H	ALA271
H	GLN275
H	PHE313
H	ARG316
H	LEU326
H	ALA327
H	ILE345
H	CYS432

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 502

Chain	Residue
H	CYS135
H	CYS138
H	CYS152
H	CYS155

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 503

Chain	Residue
H	CYS171
H	CYS177
H	CYS187
H	CYS190

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 965 I 501

Chain	Residue
I	PHE271
I	LEU274
I	ALA275
I	SER278
I	GLU281
I	MET312
I	LEU313
I	THR316
I	ARG319
I	PHE329
I	LEU330
I	PHE340
I	LEU345
I	PHE349
I	ILE350
I	ILE353
I	PHE354
I	HIS435
I	TRP457

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 502

Chain	Residue
I	CYS87
I	CYS90
I	CYS104
I	CYS107

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 503

Chain	Residue
I	CYS125
I	CYS131
I	CYS141
I	CYS144

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR

Chain	Residue	Details
A	CYS135-ARG161
B	CYS87-ARG113

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	284
Details	DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	176
Details	Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"12145331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10669605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BY4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"17761950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"UniProtKB","id":"P28700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	23
Details	Region: {"description":"Hinge"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	70
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	16
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"20159957","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	16
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)