4NM8
Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Hemagglutinin HA1 Chain | polymer | 323 | 35506.9 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 2 | B, D, F (B, D, F) | Hemagglutinin HA2 Chain | polymer | 176 | 20197.3 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 3 | G, I, K (L, M, N) | Antibody CR8043, Light Chain | polymer | 220 | 24228.8 | 3 | UniProt (P0DOX7) Pfam (PF07654) UniProt (by SIFTS) (P01834) | Homo sapiens (human) | Immunoglobulin kappa light chain EU |
| 4 | H, J, L (H, I, J) | Antibody CR8043, Heavy Chain | polymer | 230 | 24753.7 | 3 | UniProt (Q6N089) Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (S6C4S0) | Homo sapiens (human) | |
| 5 | M, N, O, P, Q... (G, K, O, P, Q...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 6 | S, T, U, V, W... (B, C, D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
A, C, E: 11 - 329 (UniProt: Q91MA7)
B, D, F: 1 - 176 (UniProt: Q91MA7)
L, M, N: 1 - 114 (PDB: 4NM8)
L, M, N: 115 - 214 (UniProt: P0DOX7)
H, I, J: 1 - 121 (PDB: 4NM8)
H, I, J: 122 - 216 (UniProt: Q6N089)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | Arg 468 | conflict |
L, M, N: 115 - 214 (UniProt: P0DOX7)
H, I, J: 1 - 121 (PDB: 4NM8)
H, I, J: 122 - 216 (UniProt: Q6N089)
| PDB | External Database | Details |
|---|---|---|
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 314060.3 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 318376.4 |
