4NM5

Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GSK3B protein	polymer	377	42857.2	1	UniProt (Q6FI27) Pfam (PF00069) UniProt (by SIFTS) (P49841) In PDB	Homo sapiens (human)	GSK3beta isoform, Glycogen synthase kinase 3 beta, isoform CRA_b, cDNA FLJ75266, highly similar to Homo sapiens glycogen synthase kinase 3 beta, mRNA
2	B	Axin-1	polymer	24	2738.1	1	UniProt (O15169) In PDB	Homo sapiens (human)	Axis inhibition protein 1, hAxin
3	C	Phosphorylated Wnt receptor LRP6 c-motif	polymer	9	1060.1	1	UniProt (by SIFTS) (O75581) In PDB	Homo sapiens
4	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	A	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8		water	water		18.0	121	Chemie (HOH)

Sequence modifications

A: 13 - 383 (UniProt: Q6FI27)

PDB	External Database	Details
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

B: 383 - 402 (UniProt: O15169)

PDB	External Database	Details
Gly 379	-	expression tag
Gly 380	-	expression tag
Ile 381	-	expression tag
Leu 382	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46655.4
Non-Polymers*	Number of molecules	8
	Total formula weight	879.6
All*	Total formula weight	47535.1

*Water molecules are not included.