4NM5
Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GSK3B protein | polymer | 377 | 42857.2 | 1 | UniProt (Q6FI27) Pfam (PF00069) UniProt (by SIFTS) (P49841) | Homo sapiens (human) | GSK3beta isoform, Glycogen synthase kinase 3 beta, isoform CRA_b, cDNA FLJ75266, highly similar to Homo sapiens glycogen synthase kinase 3 beta, mRNA |
| 2 | B (B) | Axin-1 | polymer | 24 | 2738.1 | 1 | UniProt (O15169) | Homo sapiens (human) | Axis inhibition protein 1, hAxin |
| 3 | C (C) | Phosphorylated Wnt receptor LRP6 c-motif | polymer | 9 | 1060.1 | 1 | UniProt (by SIFTS) (O75581) | Homo sapiens | |
| 4 | D (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | E, F, G, H (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | I, J (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | L, M (A, B) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A: 13 - 383 (UniProt: Q6FI27)
B: 383 - 402 (UniProt: O15169)
| PDB | External Database | Details |
|---|---|---|
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Ile 381 | - | expression tag |
| Leu 382 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 46655.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 879.6 | |
| All* | Total formula weight | 47535.1 |
