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4NM5

Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ADP A 401
ChainResidue
APHE67
AARG141
AGLN185
AASN186
AASP200
AMG406
AMG407
AHOH554
AHOH572
AALA83
ALYS85
AVAL110
ALEU132
AASP133
ATYR134
AVAL135
ATHR138

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 402
ChainResidue
ATYR56
ALYS86
ASER118
AASN129

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 403
ChainResidue
AARG144
AARG148
ALYS150
ALEU252
AGLN254
APRO255

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 404
ChainResidue
AARG319
ATHR326
AALA327
AARG328
ATHR330
AGLU333

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 405
ChainResidue
ALYS271
AHIS299

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 406
ChainResidue
AASN186
AASP200
AADP401
AHOH572

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 407
ChainResidue
AASP200
AGLY202
AADP401
AHOH537

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 408
ChainResidue
AILE296
ALYS297

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP181

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006
ChainResidueDetails
ALYS85

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422
ChainResidueDetails
ATYR216

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:35606353
ChainResidueDetails
ACYS14

224004

PDB entries from 2024-08-21

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